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POLOXAMINE 908.

Valuable CAS 11111-34-5 / SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

Poloxamine 908 is a nonionic polymer and surfactant, structurally designed with blocks of ethylene oxide and propylene oxide around a central ethylenediamine core. This amphiphilic composition allows it to effectively reduce surface tension, promoting the stable integration of immiscible oil and water phases within cosmetic formulations. It functions primarily as an emulsifier, solubilizer, and stabilizer.

Summary

Emulsifier Solubilizer Stabilizer Cleansing Agent Surfactant

Science

Mechanism of Action

At a molecular level, Poloxamine 908's amphiphilic nature enables it to significantly decrease the surface tension of liquids, which is critical for creating and maintaining stable emulsions by forming an interface between hydrophobic and hydrophilic components. While specific data on its direct mechanism within skin cells is limited, its general surfactant properties, similar to related poloxamines, suggest a potential role in lowering surface tension to assist in cleansing and maintaining a stable dermal environment.

Research

Clinical Evidence

Low confidence
Effective range 1–25%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Poloxamine 908 exhibits stability across a broad pH range and maintains integrity under recommended storage conditions. Protection from extreme temperatures and direct sunlight is advisable. It is important to note that chemical modifications, such as the protonation of its amine groups, can significantly alter its physical and biological characteristics.

Synergies

  • Cetyl Dimethicone Copolyol (for stable water/oil/water multiple emulsions)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Poloxamine 908 is generally regarded as safe for use in cosmetic and personal care products when applied within recommended guidelines. However, a dedicated safety assessment by the Cosmetic Ingredient Review (CIR) Expert Panel or the Scientific Committee on Consumer Safety (SCCS) has not been published. While the FDA does not pre-approve cosmetic ingredients, Poloxamine 908 is listed in its Global Substance Registration System. In vitro studies at concentrations ≥ 25% w/w showed a slight, delayed decrease in human keratinocyte viability, a concentration significantly higher than typical cosmetic usage for emulsification.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Poloxamine 908 is a valuable ingredient for its robust emulsifying, solubilizing, and stabilizing properties, crucial for optimizing the formulation and stability of a wide range of cosmetic products.

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