Science
Mechanism of Action
Poloxamine 704 is structurally defined as a synthetic block copolymer, part of the poloxamine subgroup. Its architecture features a central ethylenediamine core from which four arms of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) blocks extend. This distinct arrangement imparts amphiphilic characteristics, granting it both hydrophilic (water-loving) and hydrophobic (oil-loving) properties. In formulations, it acts as a surfactant, effectively lowering the interfacial tension between disparate phases such as oil and water, thereby enabling the formation of stable, finely dispersed emulsions. It also serves as an emulsifier, stabilizing these systems, and as a solubilizer, allowing for the homogenous integration of oil-soluble compounds into water-based formulations. The central diamine group is capable of protonation, which can result in a positively charged molecular structure.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Poloxamine 704's role is primarily as a sophisticated formulation aid, functioning as an emulsifier and solubilizer. It does not possess direct skin-modifying properties typically associated with active ingredients that are subject to 'dusting' or over-representation in product marketing.
The Formula
Formulation
Stability
Poloxamines, including Poloxamine 704, exhibit general stability across a broad pH spectrum, making them adaptable for diverse formulations. While specific numerical optimal pH values for Poloxamine 704's stability were not identified, the critical micelle concentration (CMC) of poloxamines is known to increase as pH decreases.
Safety
Safety Profile
Specific assessments by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) for Poloxamine 704 were not found. However, Poloxamer 407, a related compound, is approved by the FDA as an excipient in pharmaceuticals. The Global Harmonized System (GHS) classification for Poloxamine 704 indicates an absence of specific hazard or precautionary statements.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamine 704 is a valuable functional ingredient crucial for formulating stable emulsions and effectively integrating oil-soluble components into water-based skincare products, enhancing product integrity and performance.
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