Science
Mechanism of Action
As an amphiphilic block copolymer, Poloxamer 335 acts as a potent surfactant. Its structure allows it to reduce the interfacial tension between immiscible phases, thus facilitating the creation and stabilization of emulsions. It effectively solubilizes ingredients that are typically insoluble in a given solvent. Furthermore, its amphiphilic nature enables it to interact with hydrophobic surfaces and biological membranes, forming micelles with a hydrophobic core and a hydrophilic shell above its critical micelle concentration in aqueous environments. This mechanism aids in cleansing by promoting the mixing of water with oils and dirt for efficient removal.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Poloxamer 335 primarily serves as a functional excipient in formulations, improving texture, stability, and cleansing properties, rather than being marketed for standalone 'active' skin benefits.
The Formula
Formulation
Stability
This ingredient exhibits reverse solubility; it is more soluble at lower temperatures, typically between 5–10 °C, due to increased hydration of its polymer chains. Solubility decreases as temperature rises, particularly for the polyoxypropylene (PPO) block, which can lead to microphase separation and micelle formation. At higher concentrations and elevated temperatures, Poloxamer 335 can form thermo-reversible gels.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel deemed Poloxamer 335 safe for use in cosmetics. While specific reproductive and developmental toxicity data are absent, its molecular weight and solubility characteristics suggest minimal skin penetration. The CIR Panel emphasizes strict purification protocols to maintain 1,4-dioxane levels below established safety limits, consistent with its inclusion on the FDA's list of indirect food additives and approval for pharmaceutical applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamer 335 is a valuable amphiphilic copolymer, well-tolerated across all skin types, primarily functioning as a safe and effective surfactant, solubilizer, and emulsifier to enhance product formulation stability and cleansing performance.
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References
Sources