Science
Mechanism of Action
As a nonionic triblock copolymer, Poloxamer 334 is characterized by a central hydrophobic polyoxypropylene chain flanked by two hydrophilic polyoxyethylene chains. This amphiphilic structure enables it to significantly reduce the surface tension between disparate phases, such as oil and water. This action forms stable emulsions, aids in the dispersion and rinsing away of lipophilic impurities from the skin, and improves the dissolution of components that are not readily soluble in the primary solvent system.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Poloxamers exhibit general stability; however, some grades may degrade under specific stressors like elevated temperatures (e.g., 40 °C) and high humidity (e.g., 75% RH). This degradation can yield formic acid, acetic acid, formaldehyde, and acetaldehyde, concurrently causing a pH reduction, potentially from approximately 6 to a range of 2.66-3.85. The inclusion of antioxidants is recommended to enhance stability. An optimal pH range specifically for Poloxamer 334 stability was not identified.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Poloxamer 334, along with other Poloxamers, is safe for use in cosmetic ingredients. Its molecular weight and solubility characteristics suggest minimal skin penetration. Manufacturers are advised to control and minimize levels of impurities such as 1,4-dioxane.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamer 334 is a valuable, safe, and versatile functional ingredient, essential for enhancing product stability, cleansing efficacy, and ingredient solubilization across a wide spectrum of skincare and pharmaceutical applications.
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References
Sources