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Moumoujus

POLOXAMER 238.

Valuable CAS 9003-11-6 / SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

Poloxamer 238 is a synthetic nonionic triblock copolymer, uniquely amphiphilic due to its balanced hydrophilic and hydrophobic segments. This composition enables its functionality as a highly effective surfactant, emulsifier, and solubilizer in precision skincare. It is distinguished by its low potential for dermal irritation and sensitization.

Summary

Emulsifying Surfactant Cleansing Solubilizer

Science

Mechanism of Action

Poloxamer 238 functions as a nonionic triblock copolymer, leveraging its amphiphilic structure, which consists of both water-attracting (polyoxyethylene) and oil-attracting (polyoxypropylene) segments. This enables it to significantly reduce surface tension, acting as an emulsifying agent to blend immiscible liquids. It also serves as a solubilizer, enhancing the dissolution of various ingredients, and a cleansing agent by facilitating the removal of oil-based impurities from the skin.

Research

Clinical Evidence

High confidence
Effective range 0.005–20%
Optimal

N/A

Key findings

  1. 01 Clinical evaluations consistently demonstrate Poloxamer 238's efficacy as a surfactant, emulsifying, and solubilizing agent within concentrations up to 20%, with uniformly negative results for dermal irritation and sensitization.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Poloxamer 238 is known for its thermoreversible gelation properties, capable of forming gels at body temperature, with the gelation point influenced by concentration and specific composition. High temperatures may lead to the dehydration of its polyoxypropylene blocks and collapse of polyoxyethylene chains, potentially rendering it insoluble in water. While generally pH-stable, chemically modified variants may exhibit pH sensitivity.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
20%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded Poloxamer 238 is safe for cosmetic use, supported by extensive clinical tests showing no dermal irritation or sensitization. Although comprehensive reproductive and developmental toxicity data are not explicitly available, its molecular weight and solubility profile indicate minimal skin penetration. The CIR advises stringent purification to control impurities such as 1,4-dioxane. This ingredient also holds approval for pharmaceutical applications by the US FDA and is used as a food additive.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Poloxamer 238 is a valuable amphiphilic surfactant, recognized for its low irritation potential and versatility as an effective emulsifying, solubilizing, and cleansing agent across diverse skincare formulations.

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