Science
Mechanism of Action
This ingredient functions by utilizing its distinct architecture: a central hydrophobic polyoxypropylene (PPO) chain flanked by two hydrophilic polyoxyethylene (PEO) chains. This amphiphilic character allows Poloxamer 237 to significantly reduce the surface tension of substances. This action facilitates the formation of stable emulsions and enables the solubilization of hydrophobic compounds in aqueous environments. In solutions, it can self-assemble into micelles, encapsulating oil, dirt, and other hydrophobic substances, thereby supporting effective cleansing and easy rinsing from the skin.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Clinical dermal irritation and sensitization tests conducted on poloxamers consistently yielded negative results, indicating a high level of skin tolerance.
- 02 Animal toxicity studies, utilizing concentrations of 5% w/v and 10% w/v, demonstrated that poloxamers were non-irritating and non-sensitizing when applied to ocular, oral, and dermal tissues.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Poloxamer 237 exhibits excellent stability, with aqueous solutions remaining stable across varying pH levels and in the presence of acids, alkalis, and metal ions. However, to prevent microbial growth, particularly mold, aqueous formulations require appropriate preservation. Bulk material should be stored in a well-sealed container in a cool, dry environment.
Conflicts
- Phenols
- Parabens
- Strong oxidizing agents
Safety
Safety Profile
The CIR Expert Panel has deemed Poloxamer 237, alongside other poloxamers, safe for use in cosmetic applications. It is generally recognized as a non-toxic and non-irritant material. While data on reproductive and developmental toxicity is not available, its high molecular weight and water solubility suggest minimal skin penetration. Potential trace amounts of 1,4-dioxane, a byproduct of the ethoxylation process, are controlled through stringent purification methods.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamer 237 is a valuable formulating agent due to its strong performance as a non-irritating, low-comedogenic surfactant, emulsifier, and solubilizer, making it suitable for a wide range of stable and gentle skincare applications.
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References
Sources