Science
Mechanism of Action
Functioning as a sophisticated surfactant, Poloxamer 188 Succinate efficiently reduces the surface tension between disparate substances, which is critical for forming stable emulsions. This property also allows it to act as a solubilizer, integrating components that would typically not dissolve together. In cleansing applications, it helps water effectively mix with oils and impurities on the skin and hair, allowing for easy removal. Furthermore, research on its parent compound, Poloxamer 188, indicates a potential to inhibit the growth and reproduction of microorganisms.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Information regarding stability refers to Poloxamer 188. Its degradation in solution is significantly influenced by temperature, concentration, and buffer composition. Solutions formulated at higher pH levels generally exhibit superior stability compared to more acidic environments.
Safety
Safety Profile
Safety assessments predominantly refer to Poloxamer 188, as specific evaluations for Poloxamer 188 Succinate were not identified. The Cosmetic Ingredient Review (CIR) Expert Panel deemed Poloxamer 188 and related Poloxamers safe for use in cosmetics. The FDA lists Poloxymers as indirect food additives, and Poloxamer 188 is approved for use as an antibacterial agent in Over-the-Counter (OTC) skin wound cleansers. Animal studies indicated minimal ocular irritation, but no dermal irritation or sensitization, a finding corroborated by uniformly negative clinical dermal irritation and sensitization tests in humans.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamer 188 Succinate is a valuable functional ingredient due to its effective surfactant, emulsifying, and cleansing properties, coupled with a well-established low safety risk based on its parent compound.
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References
Sources