Science
Mechanism of Action
This ingredient operates primarily by reducing the surface tension at oil-water interfaces, which is essential for stabilizing emulsions and ensuring immiscible phases blend uniformly. It also acts as a solubilizer, enabling difficult-to-dissolve components to integrate into various solvent systems. In cleansing formulations, it facilitates the interaction of water with oils and dirt, allowing for effective rinse-off. On the skin's surface, Poloxamer 182 Dibenzoate functions as a lubricating agent, directly contributing to a refined and smooth tactile finish.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Poloxamer 182 Dibenzoate is stable under typical storage conditions. For aqueous solutions at 2.5%, an optimal pH range of 5.0 to 7.5 is recommended. Formulators must implement stringent purification protocols to limit impurities such as ethylene oxide, propylene oxide, and 1,4-dioxane. Its temperature-sensitive and self-assembly characteristics allow for diverse processing methods.
Conflicts
- strong acids
- strong alkalis
- strong oxidizing agents
- strong reducing agents
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Poloxamer 182 Dibenzoate is safe for use in cosmetics, with Poloxamers generally used at concentrations up to 20%. While reproductive and developmental toxicity data are absent, its molecular weight and solubility suggest minimal and slow skin penetration. The industry is advised to maintain purification procedures to keep residual levels of ethylene oxide, propylene oxide, and 1,4-dioxane below established limits. Animal studies indicated minimal ocular irritation and no dermal irritation or sensitization, results consistent with negative clinical human tests. It is also approved by the US FDA for pharmaceutical applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A versatile and well-tolerated functional ingredient, Poloxamer 182 Dibenzoate is valuable for stabilizing emulsions, enhancing cleansing, and contributing to skin smoothness across a wide range of formulations.
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