Science
Mechanism of Action
As an amphiphilic triblock copolymer, Poloxamer 124 features a hydrophobic polyoxypropylene core flanked by two hydrophilic polyoxyethylene chains. This unique structure enables it to significantly reduce the interfacial tension between immiscible liquids like oil and water. This surfactant action facilitates the formation of stable emulsions, solubilizes various ingredients within formulations, functions as an effective cleansing agent, and can enhance the percutaneous penetration of other active compounds.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Animal toxicity studies, conducted with poloxamers including Poloxamer 124 at concentrations of 5-10% w/v, consistently demonstrated that the ingredient is non-irritating and non-sensitizing when applied to sensitive areas such as the eyes, gums, and skin.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Aqueous solutions of Poloxamer 124 exhibit robust stability in the presence of acids, alkalis, and various metal ions. However, it's crucial to note that aqueous solutions can support mold growth, necessitating proper preservation. The bulk material should be stored in a well-closed container in a cool, dry environment, with a stability period of two years below 25 °C. Properties may reversibly change if temperatures exceed 30-40 °C.
Conflicts
- Phenols (concentration-dependent)
- Parabens (concentration-dependent)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded Poloxamer 124 is safe for cosmetic applications, predicting minimal and slow skin penetration due to its molecular weight and solubility profile. The CIR panel highlighted the importance of stringent purification processes to keep trace impurities, such as ethylene oxide, propylene oxide, and 1,4-dioxane, below established safety limits. Poloxamer 124 is also approved by the US FDA for use in pharmaceutical products and has a 'safe for general or specific, limited use' designation in food.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamer 124 is a valuable, well-tolerated ingredient that significantly enhances formulation stability and efficacy across a broad spectrum of precision skincare applications, contributing to both product performance and user comfort.
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References
Sources