Science
Mechanism of Action
Poloxamer 101 functions through its amphiphilic character, derived from hydrophilic polyoxyethylene and hydrophobic polyoxypropylene segments. This structure enables it to significantly reduce surface tension, promoting the formation of stable emulsions between oil and water phases. Furthermore, it acts as a solubilizing agent, allowing ingredients to dissolve in otherwise unsuitable solvents, and enhances cleansing by binding to oily impurities for easier rinsing from the skin.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Aqueous solutions of Poloxamers demonstrate robust stability across a wide range of pH conditions, including the presence of acids, alkalis, and various metal ions. They exhibit reverse solubility, meaning their solubility increases at lower temperatures due to enhanced hydration of the copolymer chains.
Conflicts
- Potential incompatibility with phenols and parabens has been observed with other Poloxamers (e.g., Poloxamer 188), suggesting a cautious approach within this class, dependent on specific concentrations.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel affirmed Poloxamer 101's safety for cosmetic use, supported by uniformly negative results in dermal irritation and sensitization tests. Its molecular characteristics suggest minimal skin penetration. Manufacturers are advised to maintain rigorous purification protocols to ensure impurity levels, such as ethylene oxide, propylene oxide, and 1,4-dioxane, remain below established safety limits.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamer 101 is a versatile and well-tolerated ingredient, highly effective as a surfactant, emulsifier, and cleansing agent across a broad spectrum of skincare and cosmetic formulations.
Related
Similar Ingredients
Finding similar ingredients…