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Moumoujus

POGOSTEMON CABLIN LEAF/STEM EXTRACT.

Valuable CAS 84238-39-1 / ANTI-SEBORRHEIC, ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, SKIN PROTECTING

Pogostemon Cablin Leaf/Stem Extract is a multifaceted botanical ingredient celebrated for its ability to promote skin regeneration, mitigate inflammation, and exhibit broad-spectrum antimicrobial activity. It actively supports wound healing and provides antioxidant protection, contributing to overall skin health and resilience across various skin types.

Summary

Perfuming Masking Antifungal Anti-inflammatory Astringent Antiseptic Antioxidant Skin protecting Anti-seborrheic

Science

Mechanism of Action

This extract operates via several mechanisms to enhance skin health. It significantly increases keratinocyte proliferation, which is crucial for accelerating wound healing through the activation of OR2AT4 and subsequent elevation of cAMP levels. Concurrently, it exerts anti-inflammatory effects by reducing the expression of pro-inflammatory cytokines, specifically IL-6 and IL-8, in relevant skin cell models. Its inherent astringent qualities aid in tightening the skin, while its antioxidant capacity shields against oxidative stress and free radical damage. Furthermore, it delivers antimicrobial and antifungal benefits, assisting in skin purification, balancing oil production, and forming a protective barrier.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–2%
Optimal

N/A

Key findings

  1. 01 Pogostemon Cablin Extract (PCE) has been shown to increase keratinocyte proliferation, thereby accelerating wound healing processes via OR2AT4 activation and elevated cAMP levels. It also reduces IL-6 and IL-8 expression in keratinocytes and macrophages, indicating anti-inflammatory action.
  2. 02 Pogostemon cablin leaf extract containing trimethoxy flavone and pachypodol demonstrates broad-spectrum antimicrobial activity, suggesting its potential in combating skin pathogens.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The efficacy of the extract, particularly its key constituent patchouli alcohol, is susceptible to thermal degradation from high-temperature essential oil extraction methods. Its quality is also influenced by environmental factors, harvesting techniques, and post-harvest processing conditions.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Moderate

Generally considered safe within a concentration range of 0.5% to 2.0% (referencing the oil form). Undiluted application or concentrations exceeding this recommended range may lead to severe localized reactions, including irritation and burning sensations. The FDA recognizes patchouli oil as a flavoring agent.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pogostemon Cablin Leaf/Stem Extract is a valuable ingredient, providing scientifically supported benefits in skin regeneration, anti-inflammation, and antimicrobial defense, making it suitable for a broad range of skin types when precisely formulated within established safe concentrations.

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