Science
Mechanism of Action
This extract operates through several key mechanisms: tannins and saponins contribute antimicrobial and astringent actions, aiding in wound repair. Flavonoids deliver potent antioxidant and free radical scavenging activity, which is crucial for cellular protection and healing. Glycosides support collagen, enhance ingredient absorption, and provide hydration by attracting water molecules, with specific compounds like ethyl alpha-d-glucopyranoside offering additional moisturizing effects. Fatty acids such as n-decanoic acid and methyl palmitate provide anti-inflammatory and antimicrobial benefits, while plumericin exhibits strong antibacterial, antifungal, and antiviral properties.
Research
Clinical Evidence
Medium confidence10%
Transparency
Dusting Analysis
There is no specific data within the provided research to suggest this ingredient is commonly dusted or to establish dusting thresholds for topical formulations.
The Formula
Formulation
Safety
Safety Profile
Acute toxicity studies in rats showed no substantial harmful effects at doses up to 2000 mg/kg body weight, suggesting a No-Observed-Adverse-Effect Level (NOAEL) greater than 2000 mg/kg. Subacute studies at 200 mg and 400 mg/kg also revealed no significant adverse effects in rats. However, data specifically on human toxicity and long-term in-vivo toxicity for Plumeria Obtusa Leaf Cell Extract remains limited and warrants further investigation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Plumeria Obtusa Leaf Cell Extract presents a valuable profile for diverse skin types, offering significant antioxidant, soothing, and wound-healing potential based on mechanistic data and animal studies, though human clinical and long-term safety data are currently limited.
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References
Sources