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Moumoujus

PLUMBAGO ZEYLANICA ROOT EXTRACT.

Questionable / SKIN CONDITIONING

Plumbago Zeylanica Root Extract is derived from the roots of the plant, traditionally used in Ayurvedic medicine for various dermal conditions. This extract is recognized for its potential anti-inflammatory, antioxidant, and antimicrobial properties. It also demonstrates wound-healing capabilities by supporting collagen synthesis and cell regeneration.

Summary

Anti-inflammatory Antimicrobial Antioxidant Wound healing Skin conditioning Free radical scavenger Collagen synthesis booster Cell proliferation promoter Hair growth promotion (5α-reductase inhibition)

Science

Mechanism of Action

This extract exerts its effects through multiple biochemical pathways. It acts as an anti-inflammatory agent, potentially by inhibiting prostaglandin synthesis, and functions as an antioxidant and free radical scavenger, contributing to cellular protection. The main active compound, plumbagin, exhibits in vitro antimicrobial activity. Furthermore, animal studies indicate wound-healing efficacy through enhanced collagen production, accelerated wound closure, and promotion of cell migration and proliferation. Some preliminary research also suggests its potential to promote hair growth by down-regulating 5α-reductase type II (SRD5A2) expression in dermal papilla cells.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Direct regulatory status from CIR, SCCS, or FDA is not available. However, documented cases of skin irritation and toxicity exist, particularly when the raw root is applied undiluted, where it is considered a strong irritant. An 80% methanol extract exhibited moderate irritation in rabbit skin irritation tests, with a primary irritation index of 2.00, though it was a non-sensitizer in mice at concentrations of 4-10 mg/ml. Overuse of this herb may lead to adverse effects.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Plumbago Zeylanica Root Extract shows promising mechanistic benefits as an anti-inflammatory, antioxidant, and wound-healing agent; however, significant documented irritation potential and a lack of formal safety review (CIR, SCCS, FDA) and human clinical efficacy data render its suitability for precision skincare questionable.

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