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PLUKENETIA VOLUBILIS SEEDCAKE EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Plukenetia Volubilis Seedcake Extract, derived from the sacha inchi plant, is a potent ingredient recognized for its comprehensive anti-aging benefits. It actively diminishes visible signs of skin aging by improving firmness, reducing sagging, and smoothing skin texture, leading to a more defined and youthful appearance. This botanical extract contributes to skin regeneration and enhanced vitality.

Summary

Antioxidant Skin-Restoring Anti-aging Firming Smoothing Elasticity Enhancer

Science

Mechanism of Action

This extract functions through a sophisticated biological pathway, leveraging its rich composition of proteins, essential amino acids, fatty acids (such as linoleic and oleic acid), and powerful polyphenols. It strategically upregulates critical anti-aging genes, including Connective Tissue Growth Factor (CTGF) and Forkhead Box O3 (FOXO3), which are integral for maintaining dermal health. This genetic modulation fosters skin regeneration, amplifies dermal density, enhances elasticity and hydration, and provides robust antioxidant protection against free radical damage, ultimately refining skin firmness and reducing the visibility of wrinkles and roughness.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical investigations utilizing NaturePep® Sacha Inchi, a hydrolyzed form of this extract, demonstrated significant anti-aging outcomes. Participants experienced a 45% reduction in skin sagging after 28 days. Furthermore, skin roughness diminished by more than 20% across three distinct parameters within 21 days. These studies collectively confirm its ability to enhance jawline contour, restore skin structure, boost dermal density, and visibly reduce wrinkles.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract's hydrolyzed form is typically supplied in aqueous solutions, confirming its water solubility. While direct pH stability is not specified for the extract, sacha inchi proteins exhibit an isoelectric point at pH 4.5 during isolation. Given the known oxidation susceptibility of Plukenetia Volubilis Seed Oil, incorporating antioxidants or employing microencapsulation techniques may be beneficial to preserve the extract's integrity in formulations.

Synergies

  • Antioxidants
  • Microencapsulation agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not assessed this ingredient. While in vitro screenings of Sacha Inchi seeds displayed no cytotoxic effects against NIH-3T3 cells at concentrations up to 400 μg mL⁻¹, and the related Plukenetia Volubilis Seed Oil is considered non-toxic and non-sensitizing, it is important to note EWG's 'Restricted' classification for 'Hydrolyzed Plukenetia Volubilis Seed Extract' in EWG VERIFIED products. This restriction cites 'high contamination concerns' and 'limited evidence of immune toxicity or allergies' without adequate substantiation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Plukenetia Volubilis Seedcake Extract offers significant, clinically supported anti-aging benefits, making it a valuable active for improving skin firmness, texture, and overall youthful appearance, particularly when formulated to address potential stability and purity considerations.

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