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Moumoujus

PLUCHEA INDICA LEAF EXTRACT.

Valuable / SKIN CONDITIONING

Pluchea Indica Leaf Extract is a botanical active, rich in phytochemicals such as flavonoids and phenolic compounds. It demonstrates potent antioxidant capabilities, anti-inflammatory effects, and the ability to enhance cellular migration vital for skin regeneration and wound healing. This extract is positioned for precision skincare solutions targeting oxidative stress and compromised skin barriers.

Summary

Antioxidant Anti-inflammatory Wound Healing Antimicrobial Skin Regeneration

Science

Mechanism of Action

This extract operates through a multifaceted approach, primarily driven by its phenolic compounds, flavonoids, anthocyanins, and carotenoids. It exerts robust antioxidant activity by neutralizing Reactive Oxygen Species (ROS) and free radicals, thereby combating oxidative stress implicated in skin aging and hyperpigmentation. Flavonoids further bolster antioxidant defenses by scavenging free radicals and stimulating endogenous antioxidant gene expression. Its anti-inflammatory action involves inhibiting cyclooxygenase. For skin repair, the extract promotes the migration and proliferation of keratinocytes and dermal fibroblasts, while specific flavonoids accelerate epithelialization by inducing transforming growth factor beta (TGF-β) production. Additionally, it exhibits antibacterial properties against both Gram-positive and Gram-negative bacteria.

Research

Clinical Evidence

Medium confidence
Effective range 0.503–15.6%
Optimal

N/A

Key findings

  1. 01 Demonstrated potent antioxidant activity via DPPH scavenging.
  2. 02 Exhibited anti-proliferative effects against TGF-β-induced prostate stromal cells by inhibiting p-SMAD2/3 and p-ERK1/2 proteins.
  3. 03 Showed high antioxidant activity through DPPH scavenging.
  4. 04 Maintained fibroblast cell viability above 70%, indicating non-toxicity.
  5. 05 Identified as an optimal concentration for increasing the migration of oral mucosal cells, primary epidermal keratinocytes, and human dermal fibroblasts, particularly when formulated as nanoparticles to accelerate wound healing. However, it's important to note this concentration was categorized as cytotoxic to normal fibroblasts in general extract form.

Transparency

Dusting Analysis

Not commonly dusted

No specific data available regarding dusting practices or thresholds for Pluchea Indica Leaf Extract in cosmetic formulations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract is typically prepared using ethanolic or hydroalcoholic methods, indicating solubility in both water and alcohol. Nanoparticle and microemulsion formulations have been successfully employed to enhance its water solubility and colloidal stability. When incorporated into hydrogels, the extract exhibits good physicochemical stability, maintaining parameters like spreadability and homogeneity even with increased concentrations.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
15.6%
Sensitization risk Unknown

In vitro studies on normal human skin fibroblasts indicated non-cytotoxicity at concentrations up to 15.6 µg/mL, where cell viability remained above 70%. However, concentrations of 31.3 µg/mL and higher were deemed cytotoxic, resulting in fibroblast cell viability below 70%. While not formally reviewed by CIR, these findings emphasize the necessity for precise concentration control in topical formulations to ensure cellular safety.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pluchea Indica Leaf Extract offers valuable antioxidant, anti-inflammatory, and wound-healing properties, but requires precise formulation to remain within its non-cytotoxic concentration range for optimal safety and efficacy.

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