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PIPTADENIA COLUBRINA PEEL EXTRACT.

Valuable CAS - / HUMECTANT

This botanical extract, derived from the peel of Piptadenia colubrina, is a powerful ingredient for enhancing skin hydration and fortifying the skin barrier. It precisely targets key biological pathways to improve water retention and maintain epidermal integrity.

Summary

Humectant Skin conditioning Barrier support Antioxidant Anti-inflammatory Hydrating

Science

Mechanism of Action

Piptadenia Colubrina Peel Extract, also recognized as Anadenanthera Colubrina, acts as a comprehensive skin barrier protective and moisturizing agent. It promotes cellular hydration by stimulating the expression of aquaporin-3 (AQP3), a critical water channel protein, and fibronectin. The extract also upregulates the gene expression of crucial envelope proteins like filaggrin (FLG) and involucrin (INV). These proteins are essential for strong corneocyte cohesion, aiding the skin's capacity to retain water and other moisturizers, and supporting robust epidermal adhesion. Furthermore, its rich content of flavonoids and phenolic acids provides distinct anti-inflammatory and antioxidant benefits, safeguarding the skin from environmental stressors.

Research

Clinical Evidence

High confidence
Effective range 1%–3%%
Optimal

3%

Key findings

  1. 01 Demonstrated a significant reduction in transepidermal water loss (TEWL) in human volunteers, indicating enhanced barrier function and hydration.
  2. 02 In human volunteers, this concentration led to a substantial 90% increase in Aquaporin-3 (AQP3) expression, a 68% increase in Filaggrin (FLG), and a 51% increase in Involucrin (INV). Concurrently, a marked reduction in transepidermal water loss (TEWL) was observed.
  3. 03 Increased expression and immunoreactivity of AQP3 in cultured keratinocytes and human skin explants. Induced the gene expression of FLG and INV, and clinically improved skin capacitance in human volunteers, reflecting enhanced skin hydration.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Extracts from various parts of Anadenanthera colubrina have exhibited low genotoxicity and minimal cytotoxic potential in both in vivo and in vitro toxicology studies, suggesting a generally safe profile. Although specific Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) reports are not available for PIPTADENIA COLUBRINA PEEL EXTRACT, its inclusion in products certified 'SkinSAFE 100 Free' indicates an absence of common allergy-causing ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Piptadenia Colubrina Peel Extract is a valuable ingredient for advanced hydration and barrier repair, demonstrated by its ability to significantly boost key skin proteins and reduce transepidermal water loss.

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