Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

PIPERONYL GLUCOSIDE.

Valuable / SKIN PROTECTING

Piperonyl Glucoside is a sophisticated active ingredient engineered to comprehensively address skin reactivity and visible redness. It functions as a powerful anti-inflammatory and antioxidant, while also offering benefits in sebum regulation and hyperpigmentation management. This versatile compound is particularly effective for sensitive and reactive skin types.

Antioxidant Soothing Anti-inflammatory Anti-redness Sebum-regulating Anti-pigmentation Skin Protecting Anti-angiogenic

Science

This ingredient operates through several precise mechanisms to improve skin health. It profoundly reduces inflammation by modulating cytokine activity, thereby alleviating erythema. As an antioxidant, it actively scavenges reactive oxygen species, neutralizing free radicals and mitigating oxidative stress. Piperonyl Glucoside also influences melanogenesis by inhibiting key enzymes involved in pigmentation, effectively managing hyperpigmentation and diminishing dark spots. Furthermore, it helps regulate sebum production through lipogenesis modulation, which controls excessive oiliness, prevents pore congestion, and reduces the likelihood of acne breakouts. Uniquely, it inhibits TRPA1 and TRPV1 receptors, which are sensitive to temperature and food-related stressors, thereby preventing facial flushing. It also meticulously reorganizes the blood vessel network by controlling angiogenesis, enhancing vessel resistance, and reducing vessel diameter to visibly diminish redness associated with conditions such as erythrosis and rosacea.


Research

High confidence
Effective range 0.2–5%
Optimal

2%

Key findings

  1. 01 Clinical observations indicate effectiveness in reducing skin redness and demonstrating anti-angiogenic activity within a concentration range of 0.2% to 5%.
  2. 02 A 2% concentration of the Redyless® blend, which contains Piperonyl Glucoside, is a recommended use level for formulations targeting reactive and sensitive skin.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Safety

CIR Status
Safe with restrictions
Max tested
2%
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated 19 alkyl glucosides, a broader chemical group that includes Piperonyl Glucoside, concluding they are safe in current practices of use and concentration when formulated to be non-irritating. It is important to note that the stated 2% maximum concentration refers specifically to the Redyless® blend, which incorporates Piperonyl Glucoside, and not necessarily to the pure ingredient in isolation. Specific individual CIR, SCCS, or FDA safety assessments for Piperonyl Glucoside itself are not detailed in the provided data.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

Piperonyl Glucoside is a valuable multi-functional ingredient, expertly targeting redness, inflammation, and hyperpigmentation, making it highly beneficial for sensitive and reactive skin types across diverse product formulations.


Related

Finding similar ingredients…