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Moumoujus

PIPERAZINE BISFERULATE.

Insufficient Data CAS 96585-18-1 / SKIN CONDITIONING

Piperazine Bisferulate is a compound featuring ferulic acid, recognized for its dual action as a potent antioxidant and an effective anti-inflammatory agent. It operates by neutralizing free radicals and supporting the skin's natural defenses, while also moderating inflammatory responses. It also functions as a valuable skin conditioning agent.

Summary

Antioxidant Anti-inflammatory Skin Conditioning

Science

Mechanism of Action

This ingredient's primary function on the skin is rooted in its ferulic acid component, which delivers robust antioxidant activity. It efficiently scavenges free radicals and upregulates crucial endogenous antioxidant enzymes, such as superoxide dismutase and catalase, thereby actively mitigating oxidative stress. Additionally, Piperazine Bisferulate demonstrates significant anti-inflammatory effects by inhibiting the production of key pro-inflammatory cytokines, specifically tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), alongside deactivating nuclear factor-kappa B (NF-κB). These actions collectively calm inflammation and improve skin resilience. Furthermore, it acts as a skin conditioning agent, enhancing the overall feel and appearance of the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

The optimal pH range for Piperazine Bisferulate's stability in cosmetic formulations remains unestablished. While some studies on piperazine derivatives indicate noncytotoxic efficacy as permeation enhancers within a pH range of 8.7 to 9.6, this specific data point does not confirm the stability profile of Piperazine Bisferulate itself.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessment from Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) is available for Piperazine Bisferulate. It is listed in the FDA's Global Substance Registration System (UNII: OU4LRY06IK). While the raw chemical piperazine is noted for its corrosive properties, this does not directly apply to Piperazine Bisferulate in cosmetic formulations at typical usage concentrations.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Piperazine Bisferulate exhibits promising in vitro antioxidant and anti-inflammatory mechanisms, the absence of clinical efficacy data, comprehensive safety reviews, and formulation specifics limits a definitive assessment of its practical application.

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