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Moumoujus

PIPER SARMENTOSUM LEAF EXTRACT.

Valuable / SKIN CONDITIONING

Piper Sarmentosum Leaf Extract, derived from the wild betel plant, is recognized for its multifaceted benefits, primarily exhibiting potent antibacterial, antioxidant, and anti-inflammatory properties. This botanical ingredient holds promise for targeted skincare applications, addressing concerns from microbial imbalances to oxidative stress and inflammation.

Summary

Antibacterial Antioxidant Anti-inflammatory Soothing Adipogenesis Inhibitor (potential)

Science

Mechanism of Action

This extract operates by leveraging a rich profile of phytochemicals, including glycosides, flavonoids, terpenoids, alkaloids, and phenolic compounds like naringenin. These components collectively contribute to its ability to reduce oxidative stress and mitigate inflammatory responses. Furthermore, its inherent antimicrobial action helps to combat various bacteria, thereby promoting overall skin health and protection.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Inhibition of *Staphylococcus aureus* at a minimum inhibitory concentration (MIC) of 6.25 mg/mL.
  2. 02 Inhibition of *Escherichia coli* at a minimum inhibitory concentration (MIC) of 12.5 mg/mL.
  3. 03 Significant reduction of adipocytes by 48% using an aqueous fraction.
  4. 04 Demonstrated potent antioxidant activity (IC50 for DPPH scavenging).
  5. 05 Exhibited antibacterial activity with inhibition zones of 12mm against *Pseudomonas aeruginosa*, 11mm against *Staphylococcus aureus*, and 8mm against *Escherichia coli*.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract demonstrates versatility in formulation, as it can be prepared using a wide array of solvents including water, methanol, ethanol, chloroform, n-hexane, ethyl acetate, and n-butanol.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While no comprehensive regulatory review by CIR, SCCS, or FDA was found, the essential oil derived from Piper sarmentosum Roxb. exhibited a primary irritation index of 2.55, suggesting a potential for skin irritation.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Piper Sarmentosum Leaf Extract is a valuable botanical ingredient, offering significant antibacterial, antioxidant, and anti-inflammatory benefits, though formulators should note its unreviewed safety status and moderate irritation potential.

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