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Moumoujus

PIPER NIGRUM SEED OIL.

Valuable CAS 84929-41-9 / ASTRINGENT, FRAGRANCE

Piper Nigrum Seed Oil, derived from black pepper, is a stimulating and antioxidant-rich ingredient. It promotes skin vitality by enhancing microcirculation, supporting collagen synthesis, and offering benefits for skin tone and texture.

Summary

Antioxidant Tonic Refreshing Masking

Science

Mechanism of Action

This oil operates through multiple pathways to enhance skin health. Its antioxidant properties help neutralize free radicals, mitigating visible signs of aging. It stimulates microcirculation, delivering essential oxygen and nutrients to skin cells for a radiant complexion. Furthermore, it exhibits natural antimicrobial qualities that assist in maintaining clear pores and supports skin regeneration, fostering a smoother, firmer appearance by aiding collagen synthesis. A key active component, piperine, has been shown to reduce cellular tyrosinase activity by approximately 21.5% and intracellular melanin content by about 37.5% through the downregulation of tyrosinase (TYR) and TYR-related protein 1 (TRP-1) gene transcription, indicating its potential as a depigmenting agent. The oil also influences tissue remodeling, wound healing processes, and metabolism, and has been observed to inhibit the production of Collagen I, Collagen III, and plasminogen activator inhibitor 1 in human dermal fibroblasts.

Research

Clinical Evidence

Medium confidence
Effective range ≤10%
Optimal

N/A

Key findings

  1. 01 A 4% dilution of black pepper essential oil was found to be neither irritating nor sensitizing to human skin.
  2. 02 In an in vitro study, piperine, a key constituent, at 44 μM, significantly decreased cellular tyrosinase (TYR) activity by 21.51% and intracellular melanin content by 37.52% in B16F10 mouse melanoma cells, achieved by downregulating TYR and TRP-1 gene transcription.
  3. 03 Black Pepper Essential Oil demonstrated significant antiproliferative activity in human dermal fibroblasts and reduced the production of Collagen I, Collagen III, and plasminogen activator inhibitor 1, indicating potential benefits in tissue remodeling, wound healing, and metabolism.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Conflicts

  • Requires dilution in carrier oils for topical application to avoid irritation.
  • Contains allergenic components such as limonene and linalool, which may cause allergic reactions in sensitive individuals.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
10%
Pregnancy
Caution
Sensitization risk Moderate

Pure black pepper essential oil is inherently irritating to the skin and can trigger allergic reactions; therefore, it must be thoroughly diluted in carrier oils before topical application. In a skincare product, its quantity should not exceed 5-10% of the final mixture. It contains allergenic components such as limonene and linalool. A skin tolerance test is recommended before incorporation into a skincare routine. It should not be used during pregnancy or breastfeeding, or in children under 8 years of age. It has Generally Recognized as Safe (GRAS) status by the U.S. FDA as a food additive.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy High (undiluted) / low (diluted)
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Piper Nigrum Seed Oil is a valuable ingredient, demonstrating antioxidant, melanin-reducing, and tissue-remodeling benefits, provided it is properly diluted to mitigate its moderate sensitization risk and potential for irritation.

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