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Moumoujus

PIPER NIGRUM FRUIT.

Valuable CAS 84929-41-9 / SKIN CONDITIONING

Piper Nigrum Fruit, sourced from black pepper, is a potent botanical extract primarily featuring the active compound piperine. It delivers significant benefits including powerful antioxidant protection, measurable hyperpigmentation reduction, and comprehensive anti-aging support for enhanced skin health.

Summary

Antioxidant Skin Brightening Depigmenting Anti-inflammatory Antimicrobial Exfoliant (supports cell turnover) Circulation Stimulant Penetration Enhancer Wound Healing Support Anti-aging Photoprotective Pore Minimizer Erythema Reducer Refreshing Tonic

Science

Mechanism of Action

The active compound, piperine, operates through multiple precise mechanisms. It functions as a robust antioxidant, actively neutralizing free radicals responsible for cellular damage and premature aging. Regarding skin tone, piperine effectively inhibits tyrosinase activity and downregulates the transcription levels of tyrosinase (TYR) and tyrosinase-related protein 1 (TRP-1), thereby reducing melanin production. Furthermore, it exhibits anti-inflammatory and antimicrobial properties, contributing to a balanced skin microbiome. Piper Nigrum Fruit extract can also promote cellular turnover for gentle exfoliating effects, stimulate microcirculation, and act as a penetration enhancer, optimizing the absorption of other cosmetic actives. Its regenerative capabilities support wound healing by fostering fibroblast/keratinocyte proliferation and collagen deposition. For anti-aging, it inhibits collagenase and elastase activity, suppresses matrix metalloproteinase mRNA expression, and stimulates collagen synthesis, while also offering photoprotective benefits through UV absorption and antioxidant action.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

Formulations containing 4-5% Piper nigrum fruit extract have shown robust efficacy in topical applications.

Transparency

Dusting Analysis

Not commonly dusted

There is no research data to indicate that Piper Nigrum Fruit is commonly dusted or to establish a dusting threshold.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Piperine, the primary active component, is highly susceptible to degradation when exposed to light.

Synergies

  • Acts as a skin penetration enhancer, potentially increasing the bioavailability and efficacy of other co-formulated active ingredients.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not specifically evaluated Piper Nigrum Fruit Extract. However, 'PEPPER, BLACK (PIPER NIGRUM L.)' is classified as Generally Recognized As Safe (GRAS) by the FDA for food use under 21 CFR 182.1. Existing studies suggest piperine extract can be used in humans with no reported adverse effects.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Piper Nigrum Fruit is a valuable ingredient, backed by robust clinical data for its efficacy in reducing hyperpigmentation, providing antioxidant and anti-aging benefits, and enhancing overall skin health and appearance.

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