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Moumoujus

PIPER LONGUM FRUIT EXTRACT.

Valuable CAS 90082-60-3 / FRAGRANCE, TONIC

Derived from the long pepper plant, Piper Longum Fruit Extract is a multi-functional botanical celebrated for its significant anti-inflammatory and antioxidant properties. It further supports skin health through enhanced microcirculation and immunomodulatory effects, offering a comprehensive approach to skin resilience and clarity.

Summary

Anti-inflammatory Antioxidant Microcirculation Enhancer Immunomodulatory Soothing Clarifying Toning Fragrance Tonic

Science

Mechanism of Action

This extract exerts its anti-inflammatory effects by modulating the mitogen-activated protein kinase (MAPK) signaling pathway, specifically decreasing the phosphorylation of p38 and JNK, which leads to a downregulation of inflammatory markers such as iNOS and COX-2 mRNA and protein expression, and reduced secretion of IL-6 and TNF-α. It also upregulates HO-1 protein expression, a key enzyme in cellular protection. Beyond inflammation, it enhances cutaneous microcirculation, facilitating optimal delivery of oxygen and nutrients while aiding waste removal and thermal regulation. Its immunomodulatory properties fine-tune both innate and adaptive immune responses by influencing cytokine production and enhancing macrophage activity, contributing to overall skin defense. Furthermore, its antioxidant capacity helps neutralize free radicals, promoting a soothing, clarifying, and toning effect on the skin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Inhibited nitric oxide production in LPS-stimulated RAW 264.7 murine macrophages with an IC50 of 28.5 ± 0.91 µg/mL (in vitro).
  2. 02 Upregulated HO-1 protein expression by 3 to 10-fold in LPS-treated RAW 264.7 murine macrophages at concentrations of 10–100 µg/mL (in vitro).
  3. 03 Piperine, a key component, achieved 50% inhibition of DPPH radicals, demonstrating antioxidant activity at 22.66 µg/mL (in vitro).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For optimal quality, the extract should be stored in a cool, dry location, shielded from direct sunlight, ensuring a shelf life of up to 24 months.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Formal safety assessments by CIR, SCCS, or FDA for cosmetic use are currently unavailable. While The Good Scents Company reports 'None found' for GHS classifications and hazard statements, and 'Not determined' for various toxicities, INCIDecoder indicates 'No penalty' across its safety categories. Further comprehensive safety data is needed for definitive assessment.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Piper Longum Fruit Extract is a valuable ingredient, demonstrating potent anti-inflammatory, antioxidant, and microcirculation-enhancing benefits in in-vitro studies, particularly suited for sensitive and oily skin, though further human clinical data and formal safety reviews would solidify its precision application.

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