Science
Mechanism of Action
This extract operates by modulating inflammatory pathways, specifically reducing pro-inflammatory cytokines such as TNF-α and IL-1β, while simultaneously increasing anti-inflammatory cytokines like IL-4 and IL-13 within tissues. It also elevates key growth factors, including insulin-like growth factor I and vascular epidermal growth factor. Furthermore, its potent antioxidant capacity aids in ameliorating acute inflammatory responses by mitigating oxidative stress.
Research
Clinical Evidence
Low confidence2%
Transparency
Dusting Analysis
No information in the provided research data suggests this ingredient is commonly 'dusted' or used at ineffective percentages for marketing claims. Efficacy data from animal studies indicates specific effective concentrations.
The Formula
Formulation
Stability
The extract demonstrates stability during water extraction at 100°C. Its composition, rich in oligomeric proanthocyanidins and flavonoids, predicts high water solubility and stability under typical cosmetic formulation conditions.
Safety
Safety Profile
Animal studies indicated no site-specific allergic reactions or adverse systemic effects (e.g., body weight changes) at topical concentrations up to 4%. While not formally assessed by CIR, SCCS, or FDA for cosmetic use, SkinSAFE identifies it as 'Irritant Free', suggesting a low irritation potential.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Pinus Thunbergii Bark Extract offers valuable anti-inflammatory and antioxidant benefits, although its primary clinical efficacy has been demonstrated for hair growth in animal models, warranting further research for direct skincare applications.
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References
Sources