Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PIMENTA DIOICA LEAF EXTRACT.

Valuable CAS 223748-05-8 / TONIC

Derived from the leaves of the Pimenta dioica plant, this extract offers multifaceted benefits for skin. It demonstrates potent antimicrobial, antifungal, and anti-inflammatory properties, while also acting as an astringent to refine skin appearance and an antioxidant to protect against environmental stressors.

Summary

Antimicrobial Antifungal Anti-inflammatory Antioxidant Astringent

Science

Mechanism of Action

The efficacy of Pimenta dioica leaf extract stems from its rich composition, including key components like eugenol. Its antimicrobial action primarily involves increasing bacterial membrane permeability, leading to cellular leakage and shrinkage. Antifungal effects may involve inhibiting or degrading ergosterol, crucial for fungal cell membrane integrity. On the skin, it functions as an astringent, promoting temporary skin constriction and pore tightening. Furthermore, it exhibits anti-inflammatory effects by modulating inflammatory mediators and reducing edema, alongside powerful antioxidant activity attributed to its high content of phenolic compounds and flavonoids, which scavenge free radicals.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Eugenol, a principal component of Pimenta dioica essential oil, at concentrations of 0.01-0.03% in petroleum jelly, was effective in controlling Microsporum gypseum infection and improving skin lesions in an in vivo guinea pig study.
  2. 02 Essential oils extracted from Pimenta dioica demonstrated broad-spectrum antimicrobial activity against various bacterial and fungal strains, with minimal inhibitory concentrations ranging from 500-2000 µg/mL.
  3. 03 Pimenta dioica leaf essential oil exhibited antifungal activity with a minimal inhibitory concentration of 0.04% against Aspergillus flavus.
  4. 04 A chloroform extract derived from Pimenta dioica leaves showed antibacterial efficacy with Minimum Bactericidal Concentrations (MBC) between 2-5 mg/ml against ESBL-producing bacteria.

Transparency

Dusting Analysis

Not commonly dusted

No data available to assess dusting characteristics for this ingredient.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Specific optimal pH and stability notes were not provided in the research data.

Conflicts

  • The distinct, strong aroma of the essential oil component may restrict its inclusion in certain formulations.
  • Key essential oil components, such as eugenol, possess potential for irritation, corrosivity, or phytotoxicity, necessitating precise formulation to mitigate adverse skin reactions.
  • To ensure uniform dispersion of the essential oil component in aqueous systems, the incorporation of surfactants like Tween 80 may be required.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

No formal safety review by CIR, SCCS, or FDA for Pimenta dioica leaf extract was found. While general extracts are noted as non-toxic and cytoprotective, the essential oil components, particularly eugenol, have been identified as potentially irritant, corrosive, or phytotoxic depending on their specific concentration and overall formulation. Rigorous toxicity profiling and careful formulation strategies are therefore critical to ensure product safety.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pimenta dioica leaf extract presents as a valuable ingredient due to its demonstrated antimicrobial, anti-inflammatory, antioxidant, and astringent properties, although careful formulation is essential to manage potential irritation from its essential oil components.

Related

Similar Ingredients

Finding similar ingredients…