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Moumoujus

PILOCARPUS MICROPHYLLUS LEAF EXTRACT.

Valuable CAS 84604-03-5 / SKIN CONDITIONING

Pilocarpus Microphyllus Leaf Extract is a botanical ingredient derived from the Jaborandi plant, characterized by its rich content of flavonoids, such as chrysin, and imidazole alkaloids including pilocarpine. This extract delivers significant antioxidant protection and soothing anti-inflammatory properties to the skin, while also contributing to moisturization.

Summary

Antioxidant Anti-inflammatory Moisturizer/Humectant

Science

Mechanism of Action

This extract operates through a multifaceted mechanism to support skin health. Its flavonoid components, particularly chrysin, exert potent antioxidant activity by regulating key cellular pathways, specifically p38 mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-kB). This action effectively inhibits the generation of pro-inflammatory mediators, metalloproteinases (MMPs), and harmful reactive oxygen species (ROS). Furthermore, the presence of pilocarpine and other imidazole alkaloids contributes directly to its demonstrated anti-inflammatory capabilities.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for the stability of Pilocarpus Microphyllus Leaf Extract in cosmetic formulations has been definitively established. However, experimental studies have utilized buffers at pH 4, pH 5.6, and pH 6.4 for extraction and analytical purposes.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While generally regarded as non-irritating, there is a documented potential for irritation, inflammation, or dryness, particularly when combined with other ingredients known to cause sensitivity. The Cosmetic Ingredient Review (CIR) has not formally assessed the safety of this ingredient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Valuable

Pilocarpus Microphyllus Leaf Extract is a valuable botanical ingredient offering scientifically supported antioxidant and anti-inflammatory benefits, though formulators should carefully consider its potential for irritation in sensitive skin or complex formulations.

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