Science
Mechanism of Action
This ferment filtrate functions as a humectant, drawing moisture into the skin to maintain optimal hydration and establish a protective barrier against dryness. Its action extends to improving signs of aging by potentially restoring the Dermal-Epidermal Junction (DEJ) and reducing inflammation. Furthermore, it actively stimulates the synthesis of pro-collagen and elastin, crucial proteins for maintaining skin firmness and elasticity, and accelerates healthy cell renewal. The ingredient also contributes to a balanced skin micro-ecology, helps regulate sebum production by reducing cell lipid secretion, and exhibits properties that relieve irritation, resist inflammation, and provide a degree of protection against sun-induced damage.
Research
Clinical Evidence
Medium confidence5%
Key findings
- 01 A clinical study demonstrated that concentrations between 1-10 wt%, with an optimal level of 5 wt%, yielded significant effects in relieving skin, strengthening the micro-ecological barrier, controlling oil production, and offering sun protection. This specific filtrate composition contained 0.1-2.5% total protein, 1-15 μg/mL recombinant collagen, 0.1-1.5 mg/mL polysaccharide, and 0.2-1% amino acids.
- 02 Another study highlighted the ingredient's capacity to restore skin's firmness, elasticity, and texture by promoting the synthesis of pro-collagen and elastin, alongside activating healthy cell renewal for enhanced skin vitality.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While the Pichia pastoris organism itself thrives in pH ranges between 3.5 and 7.1 during fermentation, the precise optimal pH range for the stability of Pichia Pastoris Ferment Filtrate in a final cosmetic formulation has not been specified. Production processes are designed to mitigate bacterial contamination.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Panel determined there was insufficient data to assess the safety of Pichia Pastoris Ferment Filtrate under typical cosmetic use conditions, citing a lack of reported usage data. It's important to note that while Pichia pastoris, the organism, holds FDA GRAS status for certain protein products and as a feed additive, this status does not directly extend to the ferment filtrate as a cosmetic ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Pichia Pastoris Ferment Filtrate exhibits promising efficacy across multiple skin concerns, including hydration, anti-aging, and barrier support, but its safety profile requires further data for a conclusive determination.
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