PICEATANNOL.

This ingredient operates through multiple pathways to enhance skin health. As a powerful antioxidant, it actively neutralizes damage from environmental factors like UV radiation and pollution, simultaneously reducing inflammation, redness, and irritation. Piceatannol boosts skin elasticity and mitigates the appearance of fine lines and wrinkles by promoting collagen synthesis and inhibiting elastase activity. A key mechanism involves activating sirtuin 1 (SIRT1), which upregulates HAS2 expression and decreases HYAL2 expression in dermal fibroblasts, leading to increased hyaluronic acid production for superior hydration and elasticity. Furthermore, it inhibits melanogenesis and exhibits strong anti-tyrosinase activity—even surpassing kojic acid and resveratrol—by suppressing reactive oxygen species and enhancing the GSH/GSSG ratio, resulting in significant skin brightening. Piceatannol also combats acne by downregulating *P. acnes*-induced keratinocyte proliferation and inflammation via the Nrf2 pathway activation and NF-κB pathway inhibition. Its actions extend to upregulating glutathione, blocking UVB-induced reactive oxygen species, reducing matrix metalloproteinase-1 (MMP-1) activity, and stimulating collagen I and III production.