Science
Mechanism of Action
These polar steroids function as potent antioxidants, effectively chelating metal ions and neutralizing free radicals to mitigate oxidative stress and signs of aging. They support epidermal integrity by promoting keratinocyte differentiation and inhibiting collagenase, an enzyme implicated in collagen degradation. By strengthening the skin's hydric barrier and improving cell cohesion, phytoecdysteroids facilitate smoother skin texture and optimize natural exfoliation. They also possess anti-inflammatory and general skin protective properties.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 Topical application between 0.01% and 1% has demonstrated an ability to strengthen the skin's moisture barrier and enhance epidermal cell cohesion, resulting in a softer and smoother skin texture.
- 02 A 0.1% concentration incorporated into a cream emulsion was observed to improve skin smoothness and reinforce the stratum corneum, aiding in the normalization of dead cell detachment.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Phytoecdysteroids are polar steroids that exhibit solubility in both aqueous and lipophilic mediums, similar to sugar molecules. However, they are susceptible to autooxidation under alkaline conditions, indicating potential instability at higher pH levels.
Conflicts
- Alkaline environments (due to autooxidation)
Safety
Safety Profile
Generally recognized as safe for topical use and not classified as a steroid in the U.S. While included on the World Anti-Doping Agency's (WADA) 2021 Monitoring Program, studies on supplement use have shown no symptoms of liver or kidney toxicity. Pharmaceutical grade 20-hydroxyecdysone (≥97% purity) established a No Observed Adverse Effect Level (NOAEL) at 1000 mg/kg in repeated dose toxicity studies on rats (26-week) and dogs (39-week).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Phytoecdysteroids offer valuable benefits for skin health, effectively improving barrier function, enhancing smoothness, and providing antioxidant protection, particularly beneficial for dry and aging skin.
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References
Sources