Science
Mechanism of Action
This extract acts as an immunomodulator, effectively reducing inflammation by inhibiting key proinflammatory cytokines such as NF-κB and IL-6, without the adverse effects often associated with corticosteroids. It also demonstrates antimicrobial activity against harmful bacteria, supporting clearer skin. Beyond its calming effects, it stimulates collagen production, aids in moisture retention, and provides robust antioxidant defense against reactive oxygen species. Additionally, it may improve endothelial function by enhancing eNOS/NO signaling and reducing oxidative stress.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In studies on keloid fibroblast cultures, Physalis angulata extract demonstrated inhibition of cell viability at concentrations ranging from 3 µg/mL to 10 µg/mL, with an IC50 of 6.3 µg/mL. This research also explored its effects on collagen type I and TIMP-1 levels.
- 02 Antioxidant assays revealed significant activity, with 20 µg/mL of the extract providing 42% antioxidant content, increasing to 94% at a concentration of 140 µg/mL.
- 03 Safety assessments in RAW 264.7 cells showed the extract to be non-cytotoxic, maintaining cell viability above 100% at concentrations up to 500 ppm.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract exhibits versatility in formulation due to its solubility in both aqueous and ethanolic systems. This is attributed to its diverse chemical profile, with water-soluble components like saponins and ethanol-soluble compounds such as flavonoids and alkaloids. Certain glycosides present are also soluble in both polar and non-polar solvents, with Physalin D specifically noting good aqueous solubility.
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR) Expert Panel has noted insufficient data for a full assessment, in silico analyses suggest a low toxic tendency for irritation, tumorigenicity, mutagenicity, and reproductive toxicities. Furthermore, a study found Physalis angulata L fruit extract to be non-cytotoxic in RAW 264.7 cells at concentrations up to 500 ppm, suggesting a favorable cellular safety profile. Incidental inhalation from cosmetic products at low concentrations is not considered a significant exposure risk.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Physalis Angulata Extract is a valuable ingredient, offering broad-spectrum benefits from soothing inflammation and protecting against oxidative stress to supporting collagen production, making it suitable for diverse skincare applications.
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