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Moumoujus

PHYSALIS ALKEKENGI FRUIT EXTRACT.

Valuable CAS 90082-67-0 / SKIN CONDITIONING

Physalis Alkekengi Fruit Extract, derived from the vibrant Chinese Lantern plant, is a potent botanical known for its comprehensive skincare benefits. Rich in compounds that combat oxidative stress and soothe inflammation, it offers robust protection against environmental damage and helps mitigate signs of aging. This extract actively supports skin health, promoting a more resilient, calm, and radiant complexion.

Summary

skin conditioning antioxidant anti-inflammatory soothing anti-aging skin barrier support photoprotective moisturizing anti-senescent

Science

Mechanism of Action

This extract functions primarily through its powerful antioxidant capacity, neutralizing free radicals to prevent oxidative stress and premature skin aging. It significantly attenuates inflammatory responses by reducing key markers such as TNF-α, IL-6, IL-1β, and nitric oxide production, while also suppressing nitric oxide synthase (NOS) activity. Furthermore, it supports the skin's natural protective barrier, defends against environmental stressors like UV radiation and pollution, and possesses moisturizing and anti-senescent properties to enhance skin elasticity and smoothness.

Research

Clinical Evidence

High confidence
Effective range 0.001–0.02%
Optimal

N/A

Key findings

  1. 01 An oily extract from dried fruit pulp effectively reduced markers of inflammation induced by ultraviolet radiation, offered anti-aging benefits, and improved overall skin health.
  2. 02 Extracts from fruit calyces significantly attenuated nitric oxide (NO) production by 60% and downregulated mRNA levels of inflammatory factors (TNF-α, IL-6, IL-1β) in HaCaT skin cells, with non-cytotoxicity observed below 0.01%.
  3. 03 Fruit calyces extracts effectively inhibited total nitric oxide synthase (NOS) activity, a key enzyme in inflammation.
  4. 04 Physalis alkekengi fruit extract demonstrated beneficial effects on human umbilical vein endothelial cells (HUVECs) under hyperglycemic conditions, inhibiting oxidative stress, inflammation (diminished lipid peroxidation, inhibited IL-31 and IL-33 secretions, upregulated IL-10), and apoptosis without toxicity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Commonly extracted using ethanolic and hydroalcoholic methods, indicating solubility in polar solvents. An oily extract from the fruit pulp also suggests oil-soluble components. The fruit itself has a pH of approximately 3.5, but no specific optimal pH range for stability in cosmetic formulations has been identified.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While no explicit CIR, SCCS, or FDA safety assessment is available, SkinSAFE labels this ingredient as 'Irritant Free' and 'Teen SAFE', suggesting a favorable safety profile for topical application. Clinical studies noted non-cytotoxicity at effective concentrations, even at higher levels.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Physalis Alkekengi Fruit Extract is a valuable multi-functional ingredient, offering significant antioxidant, anti-inflammatory, and anti-aging benefits suitable for various skin types, particularly sensitive and dry skin.

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