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Moumoujus

PHYSALIS ALKEKENGI CALYX EXTRACT.

Valuable CAS 90082-67-0 / SKIN CONDITIONING

Physalis Alkekengi Calyx Extract, derived from the lantern plant, is a potent botanical ingredient recognized for its multifaceted benefits in precision skincare. It offers significant anti-inflammatory and antioxidant protection, actively mitigating skin irritation and oxidative stress. This extract also supports the skin's natural barrier function and exhibits antisenescent properties, contributing to overall skin resilience and youthfulness.

Summary

Antioxidant Soothing Skin-conditioning Anti-inflammatory Anti-aging Barrier Support

Science

Mechanism of Action

This extract works through several pathways to enhance skin health. It is rich in bioactive compounds, including physalins, flavonoids, and polyphenols, which collectively combat free radicals, thereby protecting against oxidative damage and supporting the skin's anti-aging mechanisms. Its primary mechanism involves powerful anti-inflammatory action, significantly reducing key inflammatory markers such as nitric oxide (NO) production and nitric oxide synthase (NOS) enzyme activity. It also inhibits the expression of pro-inflammatory cytokines like IL-1β, TNF-α, and IL-6, and decreases reactive oxygen species (ROS). Furthermore, it helps fortify the skin's natural protective barrier against environmental aggressors like pollution and UV radiation, and demonstrates antisenescent effects by attenuating markers associated with cellular aging.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The provided research does not contain information regarding dusting practices or thresholds for this ingredient in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The integrity of the extract's polyphenol content and its antioxidant activity can be influenced by the drying temperatures used during processing. While a specific pH of 4.6 ± 0.1 was mentioned for purification in one study, this does not directly specify an optimal pH range for its stability or efficacy in a final cosmetic formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

There is no established regulatory status or review by bodies such as CIR, SCCS, or FDA for this ingredient. Dermal toxicity remains undetermined in the search results. However, INCI Beauty indicates 'no penalty' across all categories, and potential irritancy is assessed as low, with non-cytotoxicity observed below 100 µg/mL in in-vitro studies.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Physalis Alkekengi Calyx Extract is a valuable ingredient, demonstrating potent anti-inflammatory, antioxidant, and anti-senescent properties beneficial for promoting skin balance, soothing irritation, and supporting overall skin health across all skin types.

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