Science
Mechanism of Action
This extract functions as a powerful antioxidant, effectively neutralizing reactive oxygen species to mitigate free radical damage that can lead to collagen degradation. It also exhibits anti-inflammatory effects by potentially inhibiting pro-inflammatory cytokine pathways. For skin tone, it provides a brightening action through the suppression of melanogenesis. Its anti-aging efficacy stems from improving skin elasticity, diminishing wrinkles, and boosting hydration, complemented by antiglycation activity that protects extracellular matrix proteins. Furthermore, the presence of flavonoids and alkaloids enables UV absorption, contributing to its anti-photoaging capacity, and it demonstrates antimicrobial effects.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies demonstrate significant antioxidant activity (IC50 of 3.01 mg/L) and moderate antiglycation activity (IC50 of 216.67 mg/L) at a concentration of 50 mg/L.
- 02 At 50 mg/L, the extract exhibited an in vitro SPF value of 5.95, indicating its potential for anti-photoaging due to inherent UV absorption capabilities.
- 03 A 30% ethanolic dried extract was successfully evaluated for in vitro release from a nanoemulsion delivery system, showcasing its suitability for advanced anti-aging product development.
- 04 Clinical evaluations of a cosmetic formulation containing the extract revealed improvements in skin elasticity, reduction of wrinkles, and an increase in skin hydration.
Transparency
Dusting Analysis
No data available to suggest common dusting practices or associated thresholds for this ingredient.
The Formula
Formulation
Stability
The key phenolic compounds, critical for the extract's antioxidant activity, maintain optimal stability in slightly acidic conditions, specifically within a pH range of 4.5 to 5.5. An optimal pH for polyphenol extraction was identified at 5.02, as acidic environments effectively inhibit enzymatic oxidation that could degrade these beneficial compounds.
Synergies
- Compatible with advanced delivery systems such as nanoemulsions, facilitating its incorporation into sophisticated anti-aging formulations.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not yet evaluated Phyllanthus Urinaria Extract, nor has the Scientific Committee on Consumer Safety (SCCS) issued an opinion. The U.S. Food and Drug Administration (FDA) has not provided a specific regulatory status or approval for its use as a cosmetic ingredient, with no general restrictions currently noted.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Phyllanthus Urinaria Extract is a valuable, multifaceted ingredient offering significant benefits across anti-aging, photo-protection, skin tone equalization, and hydration, making it a compelling choice for advanced skincare formulations.
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