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Moumoujus

PHYLLANTHUS NIRURI EXTRACT.

Valuable CAS 84775-91-7 / ANTIMICROBIAL, SKIN PROTECTING

Phyllanthus niruri extract is a potent botanical ingredient recognized for its multi-functional benefits, including strong antioxidant, anti-inflammatory, and skin-brightening properties. It actively supports skin health by mitigating signs of aging, reducing inflammation, and offering protection against environmental stressors.

Summary

Antioxidant Skin-Soothing Antimicrobial Skin protecting Anti-aging Anti-inflammatory Skin lightening

Science

Mechanism of Action

This extract operates through several key pathways to promote skin health. It efficiently neutralizes reactive oxygen species and enhances the skin's intrinsic antioxidant enzymes, which collectively help to reduce and reverse signs of skin aging. Its anti-inflammatory capabilities are mediated by inhibiting cyclooxygenase and lipoxygenase pathways, as well as reducing UV-induced pro-inflammatory mediators like IL-8. Additionally, it has been shown to inhibit collagenase, promote tropoelastin and collagen synthesis, contribute to skin tone evening, and exhibit antibacterial activity against various microbial strains.

Research

Clinical Evidence

High confidence
Effective range 0.0001–5%
Optimal

0.75%

Key findings

  1. 01 Anti-aging, anti-inflammatory, skin lightening.
  2. 02 High and stable antioxidant activity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 6.5
0 7 14

Stability

Phyllanthus niruri extract, rich in polyphenols, exhibits optimal stability and antioxidant activity within a slightly acidic pH range of 5.5-6.5, aligning well with the skin's natural pH. Storage at low temperatures is crucial to maintain its antioxidant efficacy, as elevated temperatures can diminish this benefit. The choice of cosmetic base significantly impacts stability; non-ionic emulsions are suitable for incorporating the dry extract when stored under controlled low-temperature conditions.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

Formal safety assessments by regulatory bodies such as CIR (Cosmetic Ingredient Review) or SCCS (Scientific Committee on Consumer Safety) are not readily available in the provided data. However, patent information indicates it is 'cosmetically acceptable' without undue toxicity, incompatibility, instability, irritation, or allergic response. Acute toxicity studies on aqueous leaf extract in animals suggest low toxicity (LC50 value of 532.96 µg/mL).

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Phyllanthus niruri extract is a valuable multi-functional ingredient, offering significant antioxidant, anti-inflammatory, and skin rejuvenating benefits with a favorable low irritancy and comedogenicity profile across multiple skin types.

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References

Sources