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Moumoujus

PHOLIOTA MICROSPORA POLYSACCHARIDES.

Valuable / HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Pholiota Microspora Polysaccharides are a multi-functional, mushroom-derived active ingredient recognized for its robust skin benefits. It delivers potent antioxidant and broad-spectrum photoprotective capabilities, exceptional moisturizing properties, and significant anti-aging effects. This ingredient also supports skin repair and reduces inflammation.

Summary

antioxidant anti-inflammatory moisturizing anti-aging wound healing photoprotective

Science

Mechanism of Action

This polysaccharide functions by significantly inhibiting the production of reactive oxygen species (ROS), thereby preventing oxidative damage from UVA exposure. It offers photoprotection through a 'pseudo-melanin shield effect' by absorbing UV rays, blue light, and near-infrared light. Its anti-aging action involves reducing elastase activity to preserve elastin and delay wrinkle formation, attenuating UVA-induced cellular aging by decreasing the protein expression of matrix metalloproteinases (MMP)-1, -3, and -9, and increasing tissue inhibitor metalloproteinase 1 (TIMP-1). Additionally, it actively inhibits glycation damage, enhances cellular viability for improved hydration and moisture retention, and possesses anti-inflammatory activities. The polysaccharides also promote fibroblast proliferation and migration, suggesting a role in wound healing.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Protected Hs68 cells against UVA-induced oxidative damage by inhibiting ROS production and attenuated UVA-induced cell aging by decreasing MMP-1, -3, and -9 expression, while increasing TIMP-1 protein expression by 41% to 56% respectively.
  2. 02 Demonstrated a moisturizing effect approximately 2.5 times greater than hyaluronic acid in a moisture retaining rate test.
  3. 03 Protected the viability of Methylglyoxal-induced Hs68 cells, with 1.5 mg/mL showing a higher protective effect against glycation damage.
  4. 04 Exhibited strong antioxidant and anti-collagenase activity, significantly reducing cellular ROS content and promoting L929 fibroblast proliferation and migration.
  5. 05 Showed inhibition effects on superoxide anions (63.24%), hydroxyl radicals (53.11%), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (59.33%).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

A Human Repeat Insult Patch Test (HRIPT) showed negative results, indicating a low potential for irritation or sensitization. No specific regulatory information from bodies such as CIR, SCCS, or FDA is available at this time.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pholiota Microspora Polysaccharides are a versatile and valuable ingredient, offering comprehensive benefits including superior hydration, robust antioxidant defense, broad-spectrum photoprotection, and significant anti-aging effects with a low irritation potential.

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