Science
Mechanism of Action
This extract primarily functions through its rich polysaccharide content, acting as a potent antioxidant by neutralizing reactive oxygen species (ROS) and scavenging free radicals, thereby protecting against oxidative stress and UVA-induced photoaging. It exhibits anti-inflammatory properties and anti-collagenase activity, which involves inhibiting matrix metalloproteinases that degrade extracellular matrix components. The extract also promotes cell proliferation and migration, potentially aiding in skin repair, and mitigates skin cell damage from glycation stress.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Polysaccharides within the extract demonstrated considerable antioxidant activity and provided protection against UVA-induced photoaging in human dermal fibroblasts.
- 02 Pholiota nameko Polysaccharides (PNPs) exhibited dose-dependent inhibition of collagenase, with specific fractions achieving up to 61% inhibition at 500 μg/mL.
- 03 The extract's polysaccharides effectively mitigated skin cell damage and oxidative stress resulting from glycation, enhancing cell survival and protecting against methylglyoxal-induced damage due to reduced intracellular ROS content.
- 04 In vivo studies indicate that zinc-enriched polysaccharides from Pholiota microspora demonstrate strong anti-aging capabilities by improving overall antioxidant status.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments from CIR, SCCS, or FDA were found for PHOLIOTA MICROSPORA FRUITING BODY EXTRACT.
Your Skin
Skin Compatibility
Our Assessment
Verdict
PHOLIOTA MICROSPORA FRUITING BODY EXTRACT is a valuable ingredient, demonstrating robust antioxidant, anti-photoaging, and anti-collagenase properties essential for comprehensive skin health and anti-aging formulations.
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References
Sources