Science
Mechanism of Action
This extract operates through multiple pathways to promote skin health. It functions as an anti-inflammatory agent by reducing key markers of irritation such as nitric oxide, 3-nitrotyrosine, and NF-kB expression, and by inhibiting PM2.5-induced Ca2+ influx through PAR-2 regulation. It delivers strong antioxidant protection, neutralizing free radicals and bolstering the skin's intrinsic antioxidant defenses. The ingredient also demonstrates antibacterial efficacy against acne-contributing bacteria like Propionibacterium acnes, assists in balancing sebum levels, and stimulates collagen synthesis for comprehensive anti-aging effects. Additionally, it offers soothing, moisturizing, and anti-allergic properties, contributing to gentle exfoliation and overall skin equilibrium.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Phellodendron Amurense Leaf extracts have demonstrated significant radical scavenging activity, performing comparably to vitamin E, indicating robust antioxidant potential.
- 02 Studies using Phellodendron amurense bark extract at 0.005% inhibited PM2.5-induced Ca2+ influx by 50% in human keratinocytes, suggesting notable anti-inflammatory and protective effects against pollution.
- 03 Further research with Phellodendron amurense bark extract at 0.01% showed a reversal of PAR-2 upregulation caused by PM2.5 in human keratinocytes, reinforcing its anti-inflammatory and protective capabilities.
Transparency
Dusting Analysis
Information regarding dusting analysis for this ingredient is not available in the provided research data.
The Formula
Formulation
Stability
Specific stability notes were not provided in the research data.
Safety
Safety Profile
While Phellodendron Amurense Bark Extract is generally considered safe, the CIR status for the leaf extract has not been reviewed. Some individuals, particularly those with sensitive skin, may experience irritation or allergic reactions, making a patch test advisable prior to widespread use. The Environmental Working Group (EWG) indicates low concerns for cancer, allergies & immunotoxicity, and developmental/reproductive toxicity, though it advises caution for EWG VERIFIED products without comprehensive substantiation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Phellodendron Amurense Leaf is a valuable ingredient, delivering comprehensive antioxidant and anti-inflammatory benefits, alongside antibacterial, sebum-regulating, and anti-aging properties, making it highly beneficial for diverse skin concerns.
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