Science
Mechanism of Action
This extract exerts its biological activities through its valuable peptide and polyphenol content. It functions as an antioxidant by significantly reducing the production of Reactive Oxygen Species (ROS) in dermal fibroblasts. Furthermore, it demonstrates anti-inflammatory potential by negatively influencing the release of Interleukin-6 (IL-6), a key inflammatory marker. Its comprehensive phytochemical profile, including phenolic compounds, protease inhibitors, saponins, and lectins, contributes to these beneficial effects.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No data available in the provided research to determine if this ingredient is commonly 'dusted' or at what concentrations it might become a concern.
The Formula
Formulation
Stability
The extract powder is reported to be soluble in sterile water for preparing stock solutions. However, a specific optimal pH range for its stability within cosmetic formulations has not been identified in the available research.
Safety
Safety Profile
No specific safety assessments or maximum concentration guidelines have been issued by major regulatory bodies such as CIR, SCCS, or FDA for Phaseolus coccineus seed extract. In vitro studies indicated an IC50 value for toxicity on healthy dermal fibroblasts (HDF) at 37.19 mg/mL (3.719%), suggesting limited toxicity at potentially effective concentrations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Phaseolus coccineus Seed Extract shows promising in vitro antioxidant and anti-inflammatory benefits, but further human clinical studies and regulatory assessments are needed to fully establish its efficacy and safety profile for widespread cosmetic use.
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References
Sources