Science
Mechanism of Action
This root extract exerts anti-inflammatory effects, contributing to a calmer skin appearance. It functions as a potent antioxidant, actively neutralizing free radicals, diminishing oxidative stress, and preventing lipid peroxidation. Furthermore, it exhibits antimicrobial actions against various bacteria and fungi. Its biological components are also recognized for promoting cell proliferation, aiding in tissue regeneration, enhancing overall skin protection, and boosting hydration levels.
Research
Clinical Evidence
Medium confidence0.03%
Key findings
- 01 Anti-inflammatory activity observed in vitro at concentrations of 0.005% to 0.01% (50 and 100 µg/mL).
- 02 Antioxidant activity demonstrated at an SC50 of 0.00319% (31.9 µg/mL) in a DPPH assay.
- 03 Antimicrobial and antibiofilm activity against Candida spp., S. mutans, and P. aeruginosa shown in in vitro/ex vivo studies from 0.048% to 0.193%. However, dose-dependent cytotoxicity on human gingival fibroblasts was noted, with viability between 55.1% and 65.5% at these concentrations.
- 04 Typical usage levels in cosmetic formulations are around 0.03%.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Liquid extracts should be stored in a cool, dark, and dry environment to maintain optimal potency and quality.
Safety
Safety Profile
No direct safety assessments by the Cosmetic Ingredient Review (CIR) or SCCS were found. Studies in rats indicated that the extract was devoid of local irritant action. A reported case of occupational asthma was linked to the inhalation of Brazil ginseng dust, which is not relevant to topical skincare application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Pfaffia Paniculata Root Extract is a valuable ingredient, offering broad-spectrum benefits including antioxidant, anti-inflammatory, and antimicrobial actions, alongside excellent skin compatibility.
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References
Sources