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Moumoujus

PETROSELINUM SATIVUM LEAF POWDER.

Valuable CAS 84012-33-9 / FRAGRANCE

PETROSELINUM SATIVUM LEAF POWDER, derived from parsley, is a multifaceted ingredient rich in polyphenols and vitamins, demonstrating significant antioxidant and anti-inflammatory properties. It actively supports skin barrier function, contributes to anti-aging effects, and helps regulate sebum production, making it suitable for a broad range of skin concerns.

Summary

Antioxidant Anti-inflammatory Skin Barrier Support Sebum Regulation Anti-aging Antimicrobial Skin Brightening Wound Healing Hydration

Science

Mechanism of Action

This ingredient functions by activating the Nrf2 pathway, which boosts endogenous antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT), thereby reducing reactive oxygen species (ROS) and mitigating oxidative stress. Its anti-inflammatory action is achieved through the inhibition of JAK1/STAT1 and NF-κB signaling pathways, leading to a suppression of inflammatory cytokines such as IL-33, IL-6, and IL-8. Furthermore, it enhances skin barrier integrity by increasing the expression of vital proteins like filaggrin and claudin-1. It also exhibits anti-aging potential by inhibiting key enzymes including elastase, tyrosinase, collagenase, and hyaluronidase, and provides antimicrobial activity against various microbes, including *Pseudomonas aeruginosa*.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

4%

Key findings

  1. 01 Demonstrated suppression of oxidative stress and inflammatory responses in human keratinocytes, reduction of ROS, activation of the Nrf2 pathway, enhancement of antioxidant enzymes (SOD, CAT), and suppression of inflammatory cytokines (IL-33, IL-6, IL-8). Also improved skin barrier proteins (filaggrin, claudin-1) and alleviated atopic dermatitis-like symptoms in a mouse model.
  2. 02 Effective in suppressing wound infections and enhancing the healing process of burns.
  3. 03 Showed efficacy in controlling sebum production in in vivo studies.
  4. 04 Resulted in a significant reduction of dermatological symptoms such as redness, thickness, and scaling in subjects with dermatitis.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 6.3 – 6.4
0 7 14

Stability

The powder form is generally stable when stored in an airtight container away from sunlight, humidity, and heat, maintaining its natural color and aroma. Optimal stability has been observed within a pH range of 6.3-6.4 in formulations. However, concentrations around 6% in specific mask formulations exhibited pH variations, suggesting that careful preservation strategies may be necessary for higher concentrations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Parsley (Petroselinum crispum Mill.) is considered highly tolerable, with one study reporting no adverse effects in 96.26% of participants. It is often regarded as hypoallergenic and safe for most skin types, provided it is properly formulated. Specific CIR, SCCS, or FDA safety assessments for 'PETROSELINUM SATIVUM LEAF POWDER' are not readily available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PETROSELINUM SATIVUM LEAF POWDER offers a valuable array of benefits, including robust antioxidant and anti-inflammatory action, skin barrier improvement, and effective sebum control at a 4% concentration, making it a versatile addition to precision skincare formulations.

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