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Moumoujus

PETASITES JAPONICUS JUICE.

Valuable / HUMECTANT, SKIN CONDITIONING

Derived from the butterbur plant, Petasites japonicus Juice is a botanical extract recognized for its diverse skin benefits. It offers significant anti-inflammatory, anti-allergic, and antioxidant properties, making it particularly beneficial for soothing irritated and sensitive skin. Its compounds work to mitigate various inflammatory responses and protect against oxidative stress.

Summary

antioxidant skin-soothing humectant anti-inflammatory anti-allergic

Science

Mechanism of Action

Petasites japonicus extract operates through multiple pathways to provide skin benefits. Its active components, including sesquiterpenes (petasins), polyphenolic compounds (fukinolic acid), and triterpene glycosides, are key. It effectively inhibits mast cell degranulation, thereby reducing histamine release, which is crucial for anti-allergic effects. Specific compounds like petatewalide B diminish the accumulation of immune cells such as eosinophils, macrophages, and lymphocytes, contributing to its anti-inflammatory action. Furthermore, petasitesin A and cimicifugic acid D directly inhibit the production of inflammatory mediators like prostaglandin E2 and nitric oxide (NO), with petasitesin A also suppressing the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by binding to these enzymes. Its robust antioxidant capacity stems from compounds like caffeic acid, fukinolic acid, and quercetin glycosides, which upregulate heme oxygenase 1 and thioredoxin reductases via the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, offering protection against radical damage and UV-induced inflammation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A hot water extract demonstrated inhibitory activity against nitric oxide (NO) production in RAW 264.7 cells, with an IC50 of 19 ± 4.9 µg/mL.
  2. 02 Petasites japonicus extract reduced intracellular oxidative stress in UVB-irradiated keratinocytes and decreased UVB-induced production of interleukin and prostaglandin in human HaCaT keratinocytes in a dose-dependent manner.
  3. 03 In vivo human assays examined the extract's ability to reduce erythema and inflammation due to chemical irritancy.

Transparency

Dusting Analysis

Not commonly dusted

No data is available to suggest this ingredient is commonly used at ineffective concentrations for marketing purposes.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific stability parameters and optimal pH ranges for formulation are not detailed in the provided research.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) has not specifically evaluated Petasites japonicus Juice or its extract. While the plant is consumed as food, raw or improperly processed forms can be toxic or carcinogenic due to pyrrolizidine alkaloids, necessitating pre-treatment (e.g., with ash or baking soda). Allergic reactions to the plant's scapes have been reported, and there is a potential for gastrointestinal sensitization due to cross-reactivity with other plants in the Asteraceae family (e.g., mugwort, ragweed). Individual skin responses should be carefully considered during formulation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Petasites japonicus Juice is a valuable botanical ingredient offering robust anti-inflammatory, anti-allergic, and antioxidant benefits for diverse skin types, though careful consideration of its processing and individual sensitization potential is warranted.

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