Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PETASITES HYBRIDUS LEAF EXTRACT.

Valuable CAS 90082-63-6 / SKIN CONDITIONING

Petasites Hybridus Leaf Extract, derived from the common butterbur plant, is a botanical powerhouse for soothing reactive skin. This oil-soluble extract, rich in active constituents like petasin and isopetasin, is meticulously processed to deliver potent anti-inflammatory and antioxidant benefits, specifically targeting irritation and redness.

Summary

Anti-inflammatory Soothing Antioxidant Skin conditioning Anti-redness

Science

Mechanism of Action

This extract modulates inflammatory responses by inhibiting the synthesis and secretion of pro-inflammatory cytokines and leukotrienes, including Cys-LT and LTB4, within human macrophages. It also effectively blocks the degranulation of activated mast cells and eosinophils, crucial cellular events in allergic and inflammatory pathways. Petasin contributes antispasmodic properties, while isopetasin influences prostaglandin metabolism. Furthermore, the essential oil components, notably fukinanolide, provide significant antioxidant activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An essential oil derived from Petasites hybridus leaves, containing 33.42% fukinanolide at a 40% concentration, demonstrated robust local anti-inflammatory activity in a Carrageenan-induced paw edema model in rats.
  2. 02 Oral administration of a Petasites hybridus leaf extract (Ze 339), standardized to 8 mg total petasins per tablet and taken twice daily for one week, significantly ameliorated nasal symptoms and reduced histamine and leukotriene levels in patients suffering from allergic rhinitis. While an oral study, it highlights the extract's systemic anti-inflammatory and anti-allergic efficacy.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

A crude extract requires processing in an aqueous medium with a pH value ≤4 to ensure complete removal of toxic pyrrolizidine alkaloids (PAs), which is critical for product safety and stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Raw, unprocessed Petasites hybridus should not be used due to the presence of hepatotoxic, carcinogenic, and mutagenic pyrrolizidine alkaloids (PAs). For skincare, it is paramount to utilize specially processed extracts that are rigorously tested to be virtually free of PAs. When PA-free, such as the Ze 339 extract, the ingredient has shown a favorable safety profile and good tolerability in clinical applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Petasites Hybridus Leaf Extract is a valuable ingredient for mitigating inflammation and soothing sensitive skin, leveraging its scientifically supported anti-inflammatory and antioxidant properties, provided it is meticulously processed to be free of toxic pyrrolizidine alkaloids.

Related

Similar Ingredients

Finding similar ingredients…