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PERSEA GRATISSIMA OIL UNSAPONIFIABLES.

Valuable CAS 91770-40-0 / HAIR CONDITIONING, SKIN CONDITIONING

Persea Gratissima Oil Unsaponifiables represent a highly concentrated extract derived from avocado oil, rich in beneficial phytosterols and the antioxidant α-Tocopherol (Vitamin E). This ingredient is formulated to enhance skin barrier function, deliver significant anti-inflammatory action, and support tissue repair mechanisms.

Summary

Antioxidant Skin-identical ingredient Emollient Skin-softening Skin conditioning Hair conditioning Anti-inflammatory Photoprotective Collagen synthesis stimulation Barrier support

Science

Mechanism of Action

This ingredient functions through its primary components: skin-nourishing phytosterols, such as β-Sitosterol and campesterol, which are structurally similar to cholesterol, thereby fortifying the skin's natural barrier. Additionally, its α-Tocopherol content provides robust antioxidant defense. Mechanistically, it stimulates the dermal synthesis of essential structural components like collagen and aggrecan, while simultaneously inhibiting key inflammatory cytokines (IL-1, IL-6, IL-8, TNF, and PGE2) by modulating the NF-kappaB pathway. This dual action confers significant anti-inflammatory and reparative benefits. Furthermore, these sterols offer photoprotective qualities, mitigating UVB-induced damage by suppressing pro-inflammatory mediators.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Oral administration of Avocado/Soybean Unsaponifiables (ASU) was shown to stimulate the synthesis of collagen and aggrecan, while inhibiting inflammatory cytokines (IL-1, IL-6, IL-8, TNF, and PGE2) through NF-kappaB modulation, demonstrating properties beneficial for tissue repair.
  2. 02 Sterols extracted from Persea gratissima oil exhibited photoprotective efficacy against UVB-induced damage by actively inhibiting pro-inflammatory mediators.

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding 'dusting' or a universally recognized minimal effective concentration for cosmetic claims is available within the provided research for this ingredient.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

In emulsion-based formulations, oxidative stability must be meticulously managed through an appropriate antioxidant strategy, primarily due to the presence of polyunsaturated fatty acids. Anhydrous systems carry a risk of gradual odor and color shifts over extended periods.

Conflicts

  • Concentrated acids
  • Alkalis
  • Oxidizing agents

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Moderate for predisposed individuals

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Persea Gratissima (Avocado) Oil, the source material, is safe for use in cosmetic and personal care products, showing no indication of skin irritation, sensitization, or general toxicity in relevant studies. The FDA also recognizes avocados as generally safe for consumption. However, it is crucial to acknowledge a documented potential for sensitization or allergic reaction to avocado in predisposed individuals. The ingredient itself is not classified as hazardous according to REACH Regulation 1907/2006 or EU Regulation 1272/2008 concerning skin irritation, eye damage, respiratory/skin sensitivity, mutagenicity, carcinogenicity, or reproductive toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Persea Gratissima Oil Unsaponifiables is a valuable, multi-functional ingredient, providing notable skin-identical nourishment, anti-inflammatory effects, collagen synthesis support, and photoprotection, suitable for a comprehensive range of skin types.

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