Science
Mechanism of Action
This extract exerts its benefits through multiple mechanisms. Rich in key bioactive components such as polyphenols and flavonoids, it functions as a potent antioxidant, effectively reducing reactive oxygen species (ROS) and promoting DNA damage repair to counteract UV-induced keratinocyte aging. Its inherent anti-inflammatory properties, attributed partly to rosmarinic acid, soothe irritated skin, diminish redness, and reduce sensitivity by inhibiting inflammatory responses and neutrophil infiltration. The extract also contributes to optimal skin hydration, enhancing elasticity, reinforcing the skin's protective barrier, and has demonstrated the ability to inhibit melanogenesis.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 A 1% topical application of Perilla Frutescens Leaf Extract (B)-BG in a scalp lotion significantly decreased scalp redness, reduced hair loss after two months, and lowered the gray hair ratio after one month, indicating improved scalp condition.
- 02 In vitro, Perilla Frutescens L. Leaves Extract (2.5-10 μg/mL) demonstrated significant inhibition of melanogenesis without cytotoxicity. A formulated serum containing this extract gradually reduced melanin and erythema index on human skin over four weeks without irritation.
- 03 Applied to mouse skin, a 5% w/v Perilla leaf extract reduced UVB-induced reactive oxygen species (ROS) levels, enhanced DNA damage repair, and increased keratinocyte colony-forming ability, suggesting protection against UV-induced skin aging.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract's bioactive polyphenol components, such as EGCG, exhibit optimal antioxidant activity within a pH range of 5-7. Anthocyanins, which contribute to the color of Perilla frutescens, are susceptible to degradation by high pH, light exposure, heat, and ionizing substances.
Safety
Safety Profile
No specific CIR or SCCS assessments for Perilla Frutescens Sprout Extract in cosmetics are available. The general Perilla frutescens plant is Generally Recognized As Safe (GRAS) for food applications. While EWG Skin Deep® lists Perilla Frutescens Leaf Extract with low concerns for toxicity and irritation, isolated reports of occupational contact dermatitis and severe allergic reactions (anaphylaxis/asthma) from the plant's seeds suggest a very low potential for sensitization in extremely sensitive individuals.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Perilla Frutescens Sprout Extract is a valuable botanical ingredient, offering comprehensive benefits for skin resilience, soothing, and anti-aging through its potent antioxidant and anti-inflammatory mechanisms.
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References
Sources