Science
Mechanism of Action
Perilla Frutescens Seed, through its oil and extracts, operates via several biological pathways to benefit the skin. Rich in phenolic compounds, flavonoids, rosmarinic acid, and triterpenoids like ursolic acid, it neutralizes free radicals, thereby mitigating oxidative stress. Its anti-inflammatory capabilities stem from components such as rosmarinic acid and alpha-linolenic acid, which modulate inflammatory mediators. The ingredient effectively inhibits melanogenesis by reducing melanin production and content, alongside suppressing collagenase activity, which is crucial for maintaining skin structure and reducing pigmentation. Furthermore, it supplies ceramide precursors, fortifying the skin's barrier function, and exhibits antibacterial qualities, contributing to overall skin integrity and hydration.
Research
Clinical Evidence
High confidence7.5%
Key findings
- 01 An extract demonstrated significant inhibitory effects on collagenase activity (82.0 ± 3.23%) in vitro at 400 µg/mL.
- 02 An extract effectively inhibited melanogenesis in B16F10 cells across a range of concentrations (1.25, 2.5, and 40 µg/mL) without inducing cell death in vitro.
- 03 A cream formulation containing Perilla frutescens seed extract clinically improved skin elasticity and reduced skin pigmentation.
- 04 An optimized cream formulation with 7.5% Perilla frutescens extract exhibited strong antioxidant activity and favorable spreadability.
Transparency
Dusting Analysis
The available research does not suggest this ingredient is commonly used in formulations for marketing claims without substantial effect.
The Formula
Formulation
Stability
Perilla frutescens seed oil, rich in unsaturated fatty acids, is susceptible to rancidity and degradation; however, its natural antioxidant content can help mitigate this. A serum containing Perilla frutescens leaf extract demonstrated stability at pH 6.0 across various storage conditions for up to 3 months.
Safety
Safety Profile
Perilla frutescens seed oil is Generally Recognized As Safe (GRAS) for food consumption. Clinical evaluations of topical applications, including seed extract creams and leaf extract serums, have reported no skin irritation or allergic reactions. While rare instances of anaphylaxis from ingestion and occupational asthma from inhalation have occurred, these are not typical for cosmetic topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Perilla Frutescens Seed is a valuable ingredient, demonstrating robust antioxidant, anti-inflammatory, and pigment-regulating effects, alongside skin barrier support, making it suitable for a broad range of skin concerns and types.
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References
Sources