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Moumoujus

PERILLA FRUTESCENS LEAF WATER.

Valuable CAS 90082-61-4 / FRAGRANCE

Perilla Frutescens Leaf Water is a botanical active, rich in polyphenols and flavonoids, offering a multi-faceted approach to skin health. It acts as a potent antioxidant, protecting skin from environmental stressors and supporting cellular repair mechanisms. Additionally, it significantly contributes to skin hydration, elasticity, and helps to soothe irritation while promoting a more even skin tone.

Summary

Antioxidant Anti-inflammatory Moisturizing Anti-aging Skin Brightening Soothing DNA Repair Support

Science

Mechanism of Action

This ingredient functions primarily through its robust content of polyphenols and flavonoids, which scavenge reactive oxygen species (ROS) and enhance DNA repair in UVB-damaged skin, providing strong antioxidant defense. It also exhibits anti-inflammatory effects by inhibiting inflammatory processes, potentially reducing histamine release from mast cells and suppressing TNF-α production. Perilla Frutescens Leaf Water improves skin's moisture barrier, leading to increased hydration and elasticity. Its ability to inhibit melanogenesis contributes to skin brightening and reduces erythema, while also offering anti-aging benefits through free radical neutralization and potential collagen support.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A 5% w/v Perilla leaf extract significantly reduced reactive oxygen species (ROS) levels and enhanced DNA damage repair in UVB-damaged mouse skin in vivo, indicating potent antioxidant and anti-photoaging potential.
  2. 02 Application of a cosmetic serum containing Perilla frutescens leaf extract over 8 weeks resulted in increased skin hydration and elasticity among 30 healthy volunteers (ages 40-60), with no reported irritation.
  3. 03 In vitro, 2.5-10 µg/mL Perilla frutescens L. leaves extract significantly inhibited melanogenesis in B16F10 cells without cytotoxicity. A formulated underarm serum containing the extract subsequently decreased melanin and erythema index on 30 Thai women over 4 weeks, demonstrating skin brightening efficacy without irritation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Functional compounds, particularly anthocyanins, are prone to degradation under high pH, light exposure, heat, and ionizing substances. For optimal stability, formulation at a lower pH and protection from light and heat are recommended.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While not reviewed by CIR, SCCS, or FDA, clinical evaluations of cosmetic formulations containing Perilla frutescens leaf extract consistently report no skin irritation or allergic reactions. Studies indicate a very low Primary Dermal Irritation Index (PDII < 0.5), suggesting it is generally non-irritating. In vitro, leaf water extract at concentrations of 12.5-100 µg/mL was found to be non-toxic to cells.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Perilla Frutescens Leaf Water is a valuable ingredient, delivering comprehensive antioxidant, anti-inflammatory, hydrating, and brightening benefits with a demonstrated low risk of irritation across all skin types.

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