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Moumoujus

PERILLA FRUTESCENS LEAF EXTRACT.

Valuable CAS 90082-61-4 / FRAGRANCE, SKIN CONDITIONING

Perilla Frutescens Leaf Extract is a potent botanical ingredient acclaimed for its significant antioxidant and anti-inflammatory capabilities. It enhances skin hydration and elasticity, while also offering notable benefits for scalp health, including reducing redness, minimizing hair loss, and decreasing the gray hair ratio.

Summary

skin conditioning antioxidant anti-inflammatory hydrating elasticity enhancer skin brightening scalp conditioning hair loss prevention anti-aging soothing

Science

Mechanism of Action

Operating as a robust antioxidant, this extract effectively diminishes reactive oxygen species (ROS) levels, boosts DNA damage repair, and safeguards against UV-induced keratinocyte aging. Its anti-inflammatory action is mediated by inhibiting key inflammatory factors such as nitric oxide (NO), NF-κB, iNOS, and COX-2, alongside reducing markers like IgE, thereby calming irritation and supporting skin repair. The extract also protects the dermal matrix from UV-induced degradation, strengthens the skin barrier, exerts antibacterial effects, and inhibits melanin production for brighter skin. In scalp care, it helps balance the scalp microbiome and prevents hair loss and graying.

Research

Clinical Evidence

Medium confidence
Effective range 1–1%
Optimal

1%

Transparency

Dusting Analysis

Not commonly dusted

Data provided does not indicate a common practice of dusting or relevant thresholds for this ingredient in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Anthocyanins, key components of Perilla frutescens leaves, are prone to degradation when exposed to high pH environments, light, heat, and ionizing substances. However, when formulated into a serum, the extract has shown stability under various storage conditions. For optimal shelf life, it is recommended to store the ingredient in a cool, dry place, away from direct sunlight.

Conflicts

  • high pH
  • light exposure
  • heat
  • ionizing substances

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Perilla extract and oil are considered possibly safe for oral intake for up to 12 months and are generally well-tolerated. A clinical evaluation of a cosmetic formulation containing the extract reported no skin irritation or allergic reactions over an 8-week period, supporting its topical safety. The European Chemicals Agency (ECHA) further indicates a 'low' concern for non-reproductive organ system toxicity and irritation (skin, eyes, or lungs).

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Perilla Frutescens Leaf Extract is a valuable, multi-beneficial ingredient offering significant antioxidant, anti-inflammatory, hydrating, and scalp-supportive effects, with a low irritation risk.

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