Science
Mechanism of Action
Perilla Frutescens Juice operates through multiple biological pathways to benefit the skin. It significantly reduces reactive oxygen species (ROS), thereby neutralizing free radicals and mitigating oxidative stress. The ingredient actively stimulates collagen production and aids in the preservation of hyaluronic acid levels, contributing to improved skin structure and hydration. Furthermore, it enhances the skin's natural ability to repair DNA damage and boosts keratinocyte colony-forming capacity, crucial for skin regeneration. Its anti-inflammatory and anti-allergic attributes help to suppress inflammatory responses and reduce irritation. Additionally, it exhibits antimicrobial/antibacterial activity and tyrosinase inhibitory properties, which can aid in managing hyperpigmentation and promoting a brighter, more even skin tone.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Perilla leaf extract at 10 µg/mL demonstrated 85.8% keratinocyte viability, reduced ROS, increased DNA damage repair, and enhanced keratinocyte colony-forming ability, with no toxic effects observed.
- 02 Perilla callus extract at 10 µg/mL and 100 µg/mL resulted in 90% and 81.4% keratinocyte viability, respectively, also showing no toxic effects.
- 03 A cosmetic serum containing an unspecified percentage of Perilla frutescens leaf extract, when clinically evaluated on human volunteers, led to increased skin hydration and elasticity, improved skin texture (e.g., narrower sulcus cutis and more equilateral triangles), with no reports of irritation or allergic reactions.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Anthocyanins, key contributors to the color of Perilla frutescens leaves, are highly susceptible to degradation. Formulations should account for this by considering lower pH environments, utilizing light-protective packaging, and employing controlled processing temperatures to preserve the integrity of these compounds, particularly in colored varieties.
Safety
Safety Profile
While 'PERILLA FRUTESCENS JUICE' or 'LEAF EXTRACT' lack specific CIR or SCCS assessments, the Perilla frutescens plant is Generally Recognized As Safe (GRAS) for food use. Clinical evaluations of cosmetic formulations containing the leaf extract consistently reported no instances of skin irritation or allergic reactions in human volunteers.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Perilla Frutescens Juice is a valuable ingredient, delivering comprehensive benefits including antioxidant protection, anti-inflammatory action, enhanced hydration, and DNA repair, making it suitable for all skin types with a low risk of irritation.
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References
Sources