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Moumoujus

PERILLA FRUTESCENS FLOWER EXTRACT.

Valuable CAS 90082-61-4 / PERFUMING

Perilla Frutescens Flower Extract is a multifaceted botanical ingredient rich in polyphenols and flavonoids, demonstrating powerful antioxidant and anti-inflammatory properties. It is clinically recognized for enhancing skin hydration, elasticity, and refining skin texture, while also contributing to a brighter, more even skin tone by inhibiting melanin production. This extract offers comprehensive benefits for age-defying, soothing, and brightening skincare formulations.

Summary

Antioxidant Anti-inflammatory Hydrating Elasticity Enhancer Skin Brightening Anti-aging Skin Texture Refining DNA Repair Support (in vitro)

Science

Mechanism of Action

This extract functions as a potent antioxidant, safeguarding skin cells from damage induced by free radicals and oxidative stress through its abundant polyphenols and flavonoids, including rosmarinic acid, caffeic acid, luteolin, and apigenin. It actively calms irritated skin and reduces redness by exhibiting anti-inflammatory effects, inhibiting key inflammatory mediators like nitric oxide (NO), reactive oxygen species (ROS), NF-κB, iNOS, and COX-2. Furthermore, it supports skin hydration and elasticity, contributes to anti-aging by promoting collagen synthesis and preserving hyaluronic acid levels, and aids in skin brightening by inhibiting melanin synthesis. In vitro research also indicates its capacity to enhance DNA repair processes in UVB-damaged cells.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An 8-week clinical trial involving 30 healthy volunteers (40-60 years old) demonstrated that a serum containing Perilla frutescens leaves extract significantly improved skin hydration and elasticity. It also refined skin texture by reducing sulcus cutis and increasing equilateral triangles, resulting in a visibly finer skin appearance, with no reported irritation or allergic reactions.
  2. 02 In a separate 4-week study with 30 Thai women, an underarm serum formulated with Perilla frutescens L. leaves extract led to a gradual decrease in melanin index by 5.38% and erythema index by 9.80%, enhancing skin tone without irritation. In vitro, the leaves extract also exhibited dose-dependent inhibition of melanogenesis in B16F10 cells at 2.5-10 µg/mL, without cytotoxicity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extraction of key active components, such as flavonoids and ortho-diphenolics, from Perilla leaf extract is most efficient at a neutral pH (pH 7). Efficiency slightly decreases at acidic pHs (pH 2 and pH 4), and recovery is lowest at alkaline pH (pH 9). Serums incorporating Perilla frutescens leaf extract have demonstrated good stability across various storage conditions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Perilla frutescens-derived products (typically from leaves or seeds) are generally recognized as safe (GRAS) by the FDA for food use, a dedicated Cosmetic Ingredient Review (CIR) or SCCS assessment for 'PERILLA FRUTESCENS FLOWER EXTRACT' in cosmetics, including a defined maximum concentration, is not currently available. However, cosmetic formulations containing general Perilla frutescens extracts have been clinically evaluated without reports of skin irritation or allergic reactions. Instances of occupational contact dermatitis have been reported in individuals directly handling the Perilla frutescens plant, but this is not directly applicable to cosmetic applications of the flower extract.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Perilla Frutescens Flower Extract is a valuable multi-functional ingredient, clinically shown to improve hydration, elasticity, and texture, while offering antioxidant, anti-inflammatory, and skin-brightening benefits suitable for a wide range of skin types.

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