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PERILLA FRUTESCENS EXTRACT.

Valuable CAS 90082-61-4 / SKIN CONDITIONING

Perilla Frutescens Extract is a multi-functional botanical ingredient renowned for its comprehensive skin benefits. Clinical studies demonstrate its ability to enhance skin elasticity and hydration, reduce pigmentation, and refine skin texture, while simultaneously offering robust antioxidant and anti-aging properties.

Summary

Antioxidant Soothing Anti-aging Brightening Hydrating Elasticity Booster DNA Repair Support

Science

Mechanism of Action

Perilla Frutescens Extract operates through a multifaceted action on the skin. Its rich content of phenolic and flavonoid compounds confers potent antioxidant activity, significantly reducing reactive oxygen species (ROS) and mitigating oxidative stress. It actively inhibits melanogenesis, suppressing melanin production for a brighter complexion, and offers anti-inflammatory benefits to soothe irritation. Furthermore, it supports anti-aging mechanisms by improving skin elasticity, inhibiting collagenase activity, and enhancing DNA repair responses in UVB-damaged keratinocytes, contributing to a refined skin texture and increased hydration.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

7.5%

Key findings

  1. 01 A cream containing Perilla frutescens seed extract improved skin elasticity and reduced pigmentation in healthy subjects (aged 35-55) after twice-daily application for four weeks.
  2. 02 A serum with Perilla frutescens leaves extract increased skin hydration and elasticity, and reduced skin texture irregularities, after 8 weeks of treatment in healthy volunteers (aged 40-60).
  3. 03 An optimized skin cream formulation with 7.5% Perilla frutescens extract demonstrated strong antioxidant activity, achieving 85.70 ± 0.45% radical inhibition.
  4. 04 In B16F10 cells, Perilla frutescens L. leaves extract at 2.5-10 µg/mL significantly inhibited melanogenesis without cytotoxicity. An underarm serum with the extract decreased melanin index by 5.38% and erythema index by 9.80% over 4 weeks.
  5. 05 Perilla frutescens pomace extract at 400 µg/mL significantly inhibited collagenase activity by 82 ± 3.23%. Clinical evaluation showed a significant decrease in skin melanin content after 4 weeks of use.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Perilla frutescens extract in serum formulations has demonstrated stability under various storage conditions. However, anthocyanins, which can contribute to the extract's pigmentation, are particularly sensitive to degradation by high pH, light exposure, heat, and ionizing substances, necessitating careful formulation and storage to preserve their integrity.

Conflicts

  • High pH
  • Light exposure
  • Heat
  • Ionizing substances

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel has categorized 'Perilla Frutescens Extract' as having insufficient data for a full safety assessment, it is generally regarded as safe for topical use, with low reported irritation in clinical trials. Perilla (Perilla frutescens) has GRAS status for food products. However, individuals with known sensitivities to plants within the Lamiaceae family should exercise caution due to a potential for allergic reactions.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Perilla Frutescens Extract is a valuable botanical ingredient, offering impressive benefits for improving skin elasticity, hydration, and tone, alongside significant antioxidant and anti-aging protection, making it suitable for a wide range of skincare applications.

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