Science
Mechanism of Action
This extract combats oxidative stress by neutralizing free radicals and diminishing reactive oxygen species (ROS) in keratinocytes, simultaneously enhancing DNA repair following UVB exposure. It exerts potent anti-inflammatory effects by regulating the keratinocyte inflammatory cascade, suppressing cytokine release through JNK activation inhibition, and preserving tight junction integrity. Furthermore, it supports skin structure by stimulating collagen production, maintaining hyaluronic acid levels, and promoting keratinocyte colony-forming ability, contributing to improved hydration, elasticity, and overall cellular renewal.
Research
Clinical Evidence
Medium confidence0.1%
Transparency
Dusting Analysis
There is no data to suggest that Perilla Frutescens Callus Culture Extract is commonly dusted or used at concentrations below its effective threshold.
The Formula
Formulation
Stability
A serum containing Perilla frutescens leaves extract demonstrated stability across various storage conditions. The cell-derived phytocomplex has been successfully incorporated into cream and mask formulations, with the latter utilizing dispersion in vegetable glycerin.
Safety
Safety Profile
No specific safety assessments by major regulatory bodies such as CIR, SCCS, or FDA are available for Perilla Frutescens Callus Culture Extract. GHS classification according to OSHA HCS indicates no hazard or precautionary statements. While oral, dermal, and inhalation toxicity data are reported as 'Not determined' by some sources, a related Perilla frutescens leaves extract showed no reports of irritation or allergic reactions in human clinical trials. Given the lack of specific irritancy testing on the callus culture extract, the sensitization risk remains unknown.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Perilla Frutescens Callus Culture Extract is a valuable ingredient for its potent antioxidant and anti-inflammatory properties, offering significant benefits for skin hydration, barrier integrity, and overall anti-aging support, particularly for dry and sensitive skin types.
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